Novel MLL-CBP fusion transcript in therapy-related chronic myelomonocytic leukemia with a t(11;16) (q23;p13) chromosome translocation

CBP, which is located on 16p13 and encodes a transcriptional adaptor/coactivator protein, has been shown to fuse by the t(8;16)(p11;p13) translocation to MOZ on 8p11 in acute myeloid leukemia. We found a t(11;16)(q23;p13) in a child with therapy‐related chronic myelomonocytic leukemia. Subsequent re...

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Bibliographic Details
Published in:Genes chromosomes & cancer 1997-09, Vol.20 (1), p.60-63
Main Authors: Satake, Noriko, Ishida, Yasushi, Otoh, Yoshiko, Hinohara, Shin-ichi, Kobayashi, Hirofumi, Sakashita, Akiko, Maseki, Nobuo, Kaneko, Yasuhiko
Format: Article
Language:English
Subjects:
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Blotting, Southern
Child
Chromosome Banding
Chromosomes, Human, Pair 11 - genetics
Chromosomes, Human, Pair 16 - genetics
CREB-Binding Protein
DNA Primers
DNA, Neoplasm - analysis
DNA-Binding Proteins - genetics
Gene Rearrangement
Histone-Lysine N-Methyltransferase
Humans
Leukemia, Myelomonocytic, Chronic - chemically induced
Leukemia, Myelomonocytic, Chronic - genetics
Male
Myeloid-Lymphoid Leukemia Protein
Neoplasms, Second Primary - genetics
Nuclear Proteins - genetics
Polymerase Chain Reaction
Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics
Proto-Oncogenes
Recombination, Genetic
Remission Induction
RNA-Directed DNA Polymerase
Sequence Analysis, DNA
Trans-Activators
Transcription Factors - genetics
Translocation, Genetic
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Description
Summary:CBP, which is located on 16p13 and encodes a transcriptional adaptor/coactivator protein, has been shown to fuse by the t(8;16)(p11;p13) translocation to MOZ on 8p11 in acute myeloid leukemia. We found a t(11;16)(q23;p13) in a child with therapy‐related chronic myelomonocytic leukemia. Subsequent reverse transcriptase‐polymerase chain reaction and direct sequencing analyses revealed the MLL‐CBP fusion transcript in CMML cells. Because 11q23 translocations involving MLL and t(8;16) involving MOZ and CBP have been reported in therapy‐related leukemias, both the MLL and CBP genes may be targets for topoisomerase II inhibitors. Accordingly, we believe that most t(11;16)‐associated leukemias may develop in patients who have been treated with cytotoxic chemotherapy for primary malignant diseases. Genes Chromosom. Cancer 20:60–63, 1997. © 1997 Wiley‐Liss, Inc.
ISSN:1045-2257
1098-2264
DOI:10.1002/(SICI)1098-2264(199709)20:1<60::AID-GCC9>3.0.CO;2-7