131I Dose-Dependent Thyroid Autoimmune Disorders in Children Living around Chernobyl

We assessed the major lymphocyte subsets in the peripheral blood, thyroid ultrasonography, levels of serum autoantibodies to thyroglobulin (AbTg), thyroid hormones, and thyroid-stimulating hormone (TSH) in 53 children without any chronic diseases living continuously around Chernobyl. The subjects ra...

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Bibliographic Details
Published in:Clinical immunology and immunopathology 1997-09, Vol.84 (3), p.251-259
Main Authors: Vykhovanets, Eugene V., Chernyshov, Victor P., Slukvin, Igor I., Antipkin, Yury G., Vasyuk, Alexander N., Klimenko, Helen F., Strauss, Kenneth W.
Format: Article
Language:English
Subjects:
Adolescent
Autoantibodies - blood
Autoimmune Diseases - etiology
Biological and medical sciences
Child
Endocrinopathies
Humans
Iodine Radioisotopes - adverse effects
Lymphocyte Count
Lymphocyte Subsets - chemistry
Lymphocyte Subsets - immunology
Medical sciences
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Radioactive Fallout
Radioactive Hazard Release
Radioactive Pollutants - adverse effects
Thyroglobulin - immunology
Thyroid Diseases - immunology
Thyroid Gland - diagnostic imaging
Thyroid Hormones - blood
Thyroid. Thyroid axis (diseases)
Thyrotropin - blood
Ukraine
Ultrasonography
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Summary:We assessed the major lymphocyte subsets in the peripheral blood, thyroid ultrasonography, levels of serum autoantibodies to thyroglobulin (AbTg), thyroid hormones, and thyroid-stimulating hormone (TSH) in 53 children without any chronic diseases living continuously around Chernobyl. The subjects ranged in age from 7 to 14 years and had different doses of131I to their thyroid. Healthy children living on noncontaminated areas were assessed as controls. The majority of children with doses of131I had normal levels of thyroid hormones. However, the percentages of positive sera for AbTg, TSH levels, ultrasonographic thyroid abnormalities, and abnormal echogenicity were significantly higher in children with doses of131I than in controls. The dose of131I to thyroid correlated positively with serum AbTg levels, percentage of CD3+CD4+ cells, and CD3+CD4+/CD3+CD8+ cell ratio and negatively with number of CD3+CD8+ and CD3−/CD16, CD56+ cells. Thus, our study demonstrates an association between dose of131I and autoimmune thyroid disorders in this population of children.
ISSN:0090-1229
1090-2341
DOI:10.1006/clin.1997.4379