Glucagon-Like Peptide-1 7-36 Amide and Peptide YY Have Additive Inhibitory Effect on Gastric Acid Secretion in Man

Background: Glucagon-like peptide-1 7-36 amide (GLP-1) and peptide YY (PYY) are colocalized in the L-cell of the ileal mucosa, and both peptides may function as enterogastrone hormones. However, it is not known whether they interact with regard to the effect on acid secretion. Methods: The effect of...

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Bibliographic Details
Published in:Scandinavian journal of gastroenterology 1997, Vol.32 (6), p.552-555
Main Authors: Wettergren, A., Maina, P., Boesby, S., Holst, J. J.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Drug Interactions
Enterogastrone
Female
Fundamental and applied biological sciences. Psychology
gastric acid
Gastric Acid - metabolism
Gastrointestinal Hormones - administration & dosage
Gastrointestinal Hormones - pharmacology
Gastrointestinal Hormones - physiology
Glucagon
Glucagon-Like Peptide 1
Glucagon-Like Peptides
Humans
Infusions, Intravenous
Male
Middle Aged
Neurotransmitter Agents - administration & dosage
Neurotransmitter Agents - pharmacology
Neurotransmitter Agents - physiology
Pentagastrin
Peptide Fragments - administration & dosage
Peptide Fragments - pharmacology
Peptide Fragments - physiology
Peptide YY
Peptides - administration & dosage
Peptides - pharmacology
Peptides - physiology
proglucagon
Stomach
Vertebrates: digestive system
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Summary:Background: Glucagon-like peptide-1 7-36 amide (GLP-1) and peptide YY (PYY) are colocalized in the L-cell of the ileal mucosa, and both peptides may function as enterogastrone hormones. However, it is not known whether they interact with regard to the effect on acid secretion. Methods: The effect of intravenous infusion of GLP-1 and PYY, either alone or in combination, on pentagastrin-induced acid secretion in eight healthy volunteers was examined. The peptides were infused at two different rates: 0.25 pmol/kg/min (low rate) and 0.5 pmol/kg/min (high rate). Results: Given alone, GLP-1 and PYY inhibited acid secretion by 26 ± 5% and 18 ± 5% (low rate) and 45 ± 8% and 38 ± 7% (high rate), respectively. Combined infusion resulted in an inhibition of 32 ± 5% (low rate) and 62 ± 7% (high rate). Both infusion rates resulted in GLP-1 and PYY plasma concentrations below or similar to postprandial levels. Conclusion: The present study suggests that the interaction between GLP-1 and PYY in man is of the additive type. The results indicate that GLP-1 and PYY have an important role in the physiologic control of gastric acid secretion.
ISSN:0036-5521
1502-7708
DOI:10.3109/00365529709025098