Fatal Bupropion Overdose

Abstract Background: Bupropion is a unique monocyclic antidepressant that has been known to cause seizures in high therapeutic doses and in acute overdoses. Death due to ingestion, however, is a rare occurrence. Case Report: We report a case of a 26-year-old man who ingested 23 g bupropion, develope...

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Bibliographic Details
Published in:Clinical toxicology (Philadelphia, Pa.) Pa.), 1997, Vol.35 (3), p.321-324
Main Authors: Harris, Carson R., Gualtieri, John, Stark, Gerrald
Format: Article
Language:English
Subjects:
Adult
Antidepressive Agents, Second-Generation - poisoning
Biological and medical sciences
Bupropion - poisoning
Dopamine - administration & dosage
Dopamine - therapeutic use
Drug intoxications. Doping
Drug Overdose
Fatal Outcome
Heart Arrest - chemically induced
Humans
Hypoxia - chemically induced
Infusions, Intravenous
Male
Medical sciences
Norepinephrine - administration & dosage
Norepinephrine - therapeutic use
Pharmacology. Drug treatments
Seizures - chemically induced
Suicide
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Summary:Abstract Background: Bupropion is a unique monocyclic antidepressant that has been known to cause seizures in high therapeutic doses and in acute overdoses. Death due to ingestion, however, is a rare occurrence. Case Report: We report a case of a 26-year-old man who ingested 23 g bupropion, developed seizures and hypoxia, and presented in cardiac arrest. The patient was resuscitated in the emergency department, but died 4 d after supportive intensive care. Conclusions: Bupropion overdose may lead to recurrent seizures, hypoxia and death. Aggressive management of severe bupropion overdose is recommended
ISSN:1556-3650
0731-3810
1556-9519
1097-9875
DOI:10.3109/15563659709001220