Familial predisposition to precancerous gastric lesions in a high-risk area of China

Aggregation of intestinal metaplasia and dysplasia was investigated among families participating in a population-based gastroscopic screening survey in an area of China with one of the world's highest rates of stomach cancer. The prevalence of gastric dysplasia was significantly increased among...

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Bibliographic Details
Published in:Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 1994-09, Vol.3 (6), p.461
Main Authors: L Zhao, W J Blot, W D Liu, Y S Chang, J S Zhang, Y R Hu, W C You, G W Xu, J F Fraumeni, Jr
Format: Article
Language:English
Subjects:
Adult
Child
China
Diet
Environment
Female
Gastritis - genetics
Gastritis, Atrophic - genetics
Gastroscopy
Helicobacter pylori - isolation & purification
Humans
Male
Metaplasia
Middle Aged
Population Surveillance
Precancerous Conditions - genetics
Precancerous Conditions - pathology
Prevalence
Risk Factors
Sex Factors
Stomach - pathology
Stomach Neoplasms - genetics
Stomach Neoplasms - pathology
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Summary:Aggregation of intestinal metaplasia and dysplasia was investigated among families participating in a population-based gastroscopic screening survey in an area of China with one of the world's highest rates of stomach cancer. The prevalence of gastric dysplasia was significantly increased among those with dysplasia among siblings or spouses, but not parents. The odds of dysplasia were nearly doubled if an eldest brother or a spouse was affected. Sibling and spousal associations for intestinal metaplasia were much less pronounced and not statistically significant. The specificity of the findings suggests that familial risk of advanced precancerous lesions (dysplasia) is influenced not only by genetic factors, but also by environmental factors operating in childhood and early adult life.
ISSN:1055-9965
1538-7755