Subclinical Effects of Chronic Increased Lead Absorption — A Prospective Study: I. Study Design and Analysis of Symptoms

Seventy workers exposed to lead for at least one year and 35 control workers have been enrolled in a prospective study of possible neurologic effects of chronic lead absorption at or below the current standard of 80 µg per 100 ml whole blood. The study design is described in detail. Initial results...

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Bibliographic Details
Published in:Journal of occupational medicine 1979-06, Vol.21 (6), p.423-429
Main Authors: Spivey, Gary H., Brown, C. Perry, Baloh, Robert W., Campion, David S., Valentine, Jane L., Massey, Frank J., Browdy, Ben L., Culver, B. Dwight
Format: Article
Language:English
Subjects:
Absorption
Adult
Central Nervous System Diseases - etiology
Humans
Lead - blood
Metallurgy
Middle Aged
Occupational Diseases - etiology
Original Articles
Pain - etiology
Prospective Studies
Research Design
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Summary:Seventy workers exposed to lead for at least one year and 35 control workers have been enrolled in a prospective study of possible neurologic effects of chronic lead absorption at or below the current standard of 80 µg per 100 ml whole blood. The study design is described in detail. Initial results of analysis of lead-related symptoms from baseline studies indicate few differences between the exposed and nonexposed workers. The majority of differences were for central nervous system (CNS) symptoms and muscle or joint pain. Little correlation was found between symptom reporting and indices of lead absorption. The evidence suggests that factors other than lead absorption itself may be important in symptom reporting.
ISSN:0096-1736
2332-3795