Proliferative and Antigenic Modifications in Human Epithelial Cells in Chronic Atrophic Gastritis

For the study of both proliferative and antigenic changes in epithelial cells in a disease predisposing to gastric cancer, endoscopic biopsy specimens were analyzed following removal from individuals with chronic atrophic gastritis (CAG); comparisons were made with specimens from normal gastric muco...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1985-10, Vol.75 (4), p.613-619
Main Authors: Lipkin, Martin, Correa, Pelayo, Mikol, Yves B., Higgins, Paul J., Cuello, Carlos, Zarama, Guillermo, Fontham, Elizabeth, Zavala, Diego
Format: Article
Language:English
Subjects:
Antigens, Neoplasm - analysis
Biological and medical sciences
Cell Division
Chronic Disease
Fetal Proteins - analysis
Gastric Mucosa - pathology
Gastritis - pathology
Gastritis, Atrophic - immunology
Gastritis, Atrophic - pathology
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Medical sciences
Stomach Neoplasms - etiology
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Thymidine - metabolism
Tritium
Tumors
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Summary:For the study of both proliferative and antigenic changes in epithelial cells in a disease predisposing to gastric cancer, endoscopic biopsy specimens were analyzed following removal from individuals with chronic atrophic gastritis (CAG); comparisons were made with specimens from normal gastric mucosa. All subjects were from Nariño, Colombia, the population of which has a high age-adjusted incidence of gastric cancer (150/100,000 population) occurring mainly in gastric antrum. After pulse incubation of biopsy specimens with tritiated thymidine ([3H]dThd), microautoradiographic distributions of [3H]dThd-labeled cells in the epithelial lining of gastric pits were correlated with expression of serologically defined γ-fetal antigen (FA) as a second marker. Measurements were done both in gastric corpus and in antrum for entire gastric pits and over multiple gastric pit compartments. Total numbers of cells per gastric pit column did not differ between the normal and the CAG specimens either in corpus or in antrum; however, both in corpus and in antrum mean numbers of [3H]dThd-labeled cells per gastric pit column and labeling index were almost twice as large for the CAG population (P
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/75.4.613