An overview of 6-shogaol: new insights into its pharmacological properties and potential therapeutic activities

Ginger ( Zingiber officinale Roscoe) has traditionally been used as a cooking spice and herbal medicine for treating nausea and vomiting. More recently, ginger was found to effectively reduce the risk of diseases such as gastroenteritis, migraine, gonarthritis, etc ., due to its various bioactive co...

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Bibliographic Details
Published in:Food & function 2024-07, Vol.15 (14), p.7252-727
Main Authors: Yang, Chenglu, Chen, Weijian, Ye, Binbin, Nie, Ke
Format: Article
Language:English
Subjects:
Antitumor activity
Bioactive compounds
Gastroenteritis
Ginger
Headache
Health risks
Herbal medicine
Migraine
Molecular modelling
Pharmacology
Phenolic compounds
Phenols
Shogaols
Vomiting
Zingiber officinale
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Summary:Ginger ( Zingiber officinale Roscoe) has traditionally been used as a cooking spice and herbal medicine for treating nausea and vomiting. More recently, ginger was found to effectively reduce the risk of diseases such as gastroenteritis, migraine, gonarthritis, etc ., due to its various bioactive compounds. 6-Shogaol, the pungent phenolic substance in ginger, is the most pharmacologically active among such compounds. The aim of the present study was to review the pharmacological characteristic of 6-shogaol, including the properties of anti-inflammatory, antioxidant and antitumour, and its corresponding molecular mechanism. With its multiple mechanisms, 6-shogaol is considered a beneficial natural compound, and therefore, this review will shed some light on the therapeutic role of 6-shogaol and provide a theoretical basis for the development and clinical application of 6-shogaol. Ginger ( Zingiber officinale Roscoe) has traditionally been used as a cooking spice and herbal medicine for treating nausea and vomiting.
ISSN:2042-6496
2042-650X
2042-650X
DOI:10.1039/d3fo04753a