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Prognostic Impact of Serum β 2 -Microglobulin Levels in Hodgkin Lymphoma Treated with ABVD or Equivalent Regimens: A Comprehensive Analysis of 915 Patients

The significance of serum beta-2 microglobulin (sβ m) in Hodgkin lymphoma (HL) is controversial. We analyzed 915 patients with HL, who were treated with ABVD or equivalent regimens with or without radiotherapy. Sβ m levels were measured by a radioimmunoassay (upper normal limit 2.4 mg/L). Sequential...

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Bibliographic Details
Published in:Cancers 2024-01, Vol.16 (2)
Main Authors: Vassilakopoulos, Theodoros P, Arapaki, Maria, Diamantopoulos, Panagiotis T, Liaskas, Athanasios, Panitsas, Fotios, Siakantaris, Marina P, Dimou, Maria, Kokoris, Styliani I, Sachanas, Sotirios, Belia, Marina, Chatzidimitriou, Chrysovalantou, Konstantinou, Elianna A, Asimakopoulos, John V, Petevi, Kyriaki, Boutsikas, George, Kanellopoulos, Alexandros, Piperidou, Alexia, Lefaki, Maria-Ekaterini, Georgopoulou, Angeliki, Kopsaftopoulou, Anastasia, Zerzi, Kalliopi, Drandakis, Ioannis, Dimopoulou, Maria N, Kyrtsonis, Marie-Christine, Tsaftaridis, Panayiotis, Plata, Eleni, Variamis, Eleni, Tsourouflis, Gerassimos, Kontopidou, Flora N, Konstantopoulos, Kostas, Pangalis, Gerassimos A, Panayiotidis, Panayiotis, Angelopoulou, Maria K
Format: Article
Language:English
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Summary:The significance of serum beta-2 microglobulin (sβ m) in Hodgkin lymphoma (HL) is controversial. We analyzed 915 patients with HL, who were treated with ABVD or equivalent regimens with or without radiotherapy. Sβ m levels were measured by a radioimmunoassay (upper normal limit 2.4 mg/L). Sequential cutoffs (1.8-3.0 by 0.1 mg/L increments, 3.5 and 4.0 mg/L) were tested along with ROC analysis. The median sβ m levels were 2.20 mg/L and were elevated (>2.4 mg/L) in 383/915 patients (41.9%). Higher sβ m was associated with inferior freedom from progression (FFP) at all tested cutoffs. The best cutoff was 2.0 mg/L (10-year FFP 83% vs. 70%, = 0.001), which performed better than the 2.4 mg/L cutoff ("normal versus high"). In multivariate analysis, sβ m > 2.0 mg/L was an independent adverse prognostic factor in the whole patient population. In multivariate overall survival analysis, sβ m levels were predictive at 2.0 mg/L cutoff in the whole patient population and in advanced stages. Similarly, sβ m > 2.0 mg/L independently predicted inferior HL-specific survival in the whole patient population. Our data suggest that higher sβ m is an independent predictor of outcome in HL but the optimal cutoff lies within the normal limits (i.e., at 2.0 mg/L) in this predominantly young patient population, performing much better than a "normal versus high" cutoff set at 2.4 mg/L.
ISSN:2072-6694
2072-6694