Solvent-free synthesis of biostable segmented polyurethane shape memory polymers for biomedical applications

Biostable shape memory polymers that remain stable in physiological conditions are beneficial for user-defined shape recovery in response to a specific stimulus. For potential commercialization and biocompatibility considerations, biomaterial synthesis must be simple and scalable. Hence, a library o...

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Bibliographic Details
Published in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2024-01, Vol.12 (5), p.1217-1231
Main Authors: Ramezani, Maryam, Getya, Dariya, Gitsov, Ivan, Monroe, Mary Beth Browning
Format: Article
Language:English
Subjects:
Biocompatibility
Biocompatible Materials - chemistry
Biomaterials
Biomedical materials
Commercialization
Glass transition temperature
Hydrogen Peroxide
Magnetic fields
Materials Testing
Melting point
Melting points
Molecular weight
Polymers
Polymers - chemistry
Polyurethane
Polyurethane resins
Polyurethanes - chemistry
Recovery
Scaffolds
Segments
Shape memory
Smart Materials
Sodium hydroxide
Solvents
Surface chemistry
Surgical implants
Thermal properties
Thermodynamic properties
Thermomechanical properties
Transition temperatures
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Summary:Biostable shape memory polymers that remain stable in physiological conditions are beneficial for user-defined shape recovery in response to a specific stimulus. For potential commercialization and biocompatibility considerations, biomaterial synthesis must be simple and scalable. Hence, a library of biostable and cytocompatible shape memory polymers with tunable thermomechanical properties based on hard segment content was synthesized using a solvent-free method. Polymer surface chemistry, thermomechanical and shape memory properties, and biostability were assessed. We also investigated the effects of processing methods on thermomechanical and shape memory properties. All polymers showed high glass transition temperatures (>50 °C), which indicates that their temporary shape could be preserved after implantation. Polymers also demonstrate high shape fixity (73-80%) and shape recovery (93-95%). Minimal mass loss (
ISSN:2050-750X
2050-7518
DOI:10.1039/d3tb02472e