Acute toxicity of pesticides in adult and weanling rats

LD50 values were determined for 57 pesticides administered by the oral or dermal route to adult male and female Sherman rats. Thirty-six of the chemicals were also tested by the oral route in one sex of weanlings. Nine pesticides tested by the oral route (bufencarb, cacodylic acid, dialifor, deltame...

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Bibliographic Details
Published in:Fundamental and applied toxicology 1986-08, Vol.7 (2), p.299-308
Main Authors: Gaines, Thomas B., Linder, Ralph E.
Format: Article
Language:English
Subjects:
Administration, Cutaneous
Administration, Oral
ADULTE
ADULTOS
ADULTS
Age Factors
Animals
Biological and medical sciences
DESTETE
Drug Evaluation, Preclinical
Female
Lethal Dose 50
Male
Medical sciences
PESTICIDE
PESTICIDES
Pesticides - toxicity
Pesticides, fertilizers and other agrochemicals toxicology
PLAGUICIDAS
RAT
RATA
RATS
SEVRAGE
TOXICIDAD
TOXICITE
TOXICITY
Toxicology
WEANING
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Summary:LD50 values were determined for 57 pesticides administered by the oral or dermal route to adult male and female Sherman rats. Thirty-six of the chemicals were also tested by the oral route in one sex of weanlings. Nine pesticides tested by the oral route (bufencarb, cacodylic acid, dialifor, deltamethrin, dicamba, diquat, quintozene, phoxim, pyrazon) and four tested by the dermal route (bufencarb, chlordimeform, dichlofenthion, leptophos) were more toxic to females than to males whereas famphur and 2,4,5-T (oral route) were less toxic to females. Eighteen of the test chemicals were more toxic to the adult than to the weanling and four compounds (leptophos, methidathion, pyrazon, and sulfoxide) were more toxic to the weanling. In additional studies the variability of the LD50 value over a 1-year period was examined for two typical insecticides. Six consecutive bimonthly oral LD50 determinations for parathion and DDT in adults of both sexes indicated that the LD50 values were little affected by the time of year that the tests were done.
ISSN:0272-0590
1095-6832
DOI:10.1016/0272-0590(86)90160-0