Effects of nano-sized sodium hexametaphosphate on the viability, metabolism, matrix composition, and structure of dual-species biofilms of Streptococcus mutans and Candida albicans

This study evaluated the effects of micrometric or nano-sized sodium hexametaphosphate (HMPnano), combined or not with fluoride (NaF, 1100 ppm), on dual-species biofilms of Streptococcus mutans and Candida albicans. Biofilms were treated with solutions containing the polyphosphates at 0.5% or 1.0%,...

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Published in:Biofouling (Chur, Switzerland) Switzerland), 2022-04, Vol.38 (4), p.321-330
Main Authors: Sampaio, Caio, Botazzo Delbem, Alberto Carlos, Hosida, Thayse Yumi, de Morais, Leonardo Antônio, Fernandes, Ana Vitória Pereira, Souza Neto, Francisco Nunes, de Camargo, Emerson Rodrigues, Monteiro, Douglas Roberto, Pessan, Juliano Pelim
Format: Article
Language:English
Subjects:
Biofilms
Biomass
Candida albicans
Carbohydrates
Colonies
Composition
Extracellular matrix
Fluorides
Metabolism
nanotechnology
Phosphates
Polyphosphates
Sodium
Streptococcus mutans
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Summary:This study evaluated the effects of micrometric or nano-sized sodium hexametaphosphate (HMPnano), combined or not with fluoride (NaF, 1100 ppm), on dual-species biofilms of Streptococcus mutans and Candida albicans. Biofilms were treated with solutions containing the polyphosphates at 0.5% or 1.0%, with/without fluoride (F), in addition to positive and negative controls. Biofilms were analysed by colony-forming units (CFU) counting, metabolic activity, production of biomass, composition of extracellular matrix, and structure. 1% HMPnano + F led to the lowest S. mutans CFU, while C. albicans CFU counts were not affected by any solution. 1% HMPnano led to the lowest metabolic activity, except for 1% HMPnano + F. All solutions promoted reductions in biofilm biomass compared to controls. Also, 1% HMPnano + F promoted the lowest concentrations of carbohydrates in the biofilm matrix, besides substantially affecting biofilms' structure. In conclusion, HMPnano and F promoted higher antibiofilm effects compared with its micrometric counterpart for most of the parameters assessed.
ISSN:0892-7014
1029-2454
DOI:10.1080/08927014.2022.2064220