From cow manure to bioactive carbon dots: a light-up probe for bioimaging investigations, glucose detection and potential immunotherapy agent for melanoma skin cancer

Bioactive carbon dots ( C-dots ) with ca. 4 nm were successfully produced with singular photophysical properties, low-toxicity and interesting immunological response. The optical properties of the C-dots were investigated and the "light-up" behaviour enabled them to be explored in glucose...

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Bibliographic Details
Published in:RSC advances 2021-02, Vol.11 (11), p.6346-6352
Main Authors: Horst, Frederico Hillesheim, Rodrigues, Carime Vitória da Silva, Carvalho, Pedro Henrique Pimenta Rocha, Leite, Amanda Monteiro, Azevedo, Ricardo Bentes, Neto, Brenno A. D, Corrêa, José Raimundo, Garcia, Mônica Pereira, Alotaibi, Saud, Henini, Mohamed, Chaves, Sacha Braun, Rodrigues, Marcelo Oliveira
Format: Article
Language:English
Subjects:
Biocompatibility
Biological activity
Cancer
Carbon dots
Chemistry
Fluorescence
Glucose
Histology
Immunology
Medical imaging
Melanoma
Necrosis
Optical properties
Skin cancer
Toxicity
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Summary:Bioactive carbon dots ( C-dots ) with ca. 4 nm were successfully produced with singular photophysical properties, low-toxicity and interesting immunological response. The optical properties of the C-dots were investigated and the "light-up" behaviour enabled them to be explored in glucose detection and bioimaging experiments (mitochondrial selective probe). C-dots were not selective to the tumour region and several fluorescent spots were visualized spread on animal bodies. The histology investigations showed that cancer-bearing mice treated with C-dots presented a large number of regions with necrosis and inflammatory infiltrates, which were not identified for cancer-bearing mice without the treatment. These results suggested that C-dots have the potential to be explored as an immune therapy agent for melanoma skin cancer . Investigation of the immunological effect of light-up carbon-dots on cancer-bearing mice.
ISSN:2046-2069
2046-2069
DOI:10.1039/d0ra10859f