Hip fractures in patients treated with antipsychotic drugs. Study of retrospective cohorts in Catalonia

To evaluate the incidence of hip fracture in patients with antipsychotic treatment, comparing it with that of individuals who have not been treated with antipsychotics. Retrospective cohort study of patients treated with antipsychotic drugs (TAP) and patients without known treatment (non-TAP). The o...

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Bibliographic Details
Published in:Atención primaria 2022-02, Vol.54 (2), p.102171
Main Authors: González Tejón, Susana, Ibarra Jato, Montserrat, Fernández San Martín, M Isabel, Prats Uribe, Albert, Real Gatius, Jordi, Martin-Lopez, Luis Miguel
Format: Article
Language:Spanish
Subjects:
Antipsychotic Agents - adverse effects
Hip Fractures - epidemiology
Humans
Incidence
Retrospective Studies
Risk Factors
Spain - epidemiology
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Summary:To evaluate the incidence of hip fracture in patients with antipsychotic treatment, comparing it with that of individuals who have not been treated with antipsychotics. Retrospective cohort study of patients treated with antipsychotic drugs (TAP) and patients without known treatment (non-TAP). The observation period was 2006-2014. SITE: All primary care teams in Catalonia of the Catalan Health Institute (ICS). Patients older than 44 years with TAP lasting at least 3 months. Control cohort: random selection of non-TAP patients matching for baseline comorbidities and other variables. A total of 22,010 are analyzed. Main measurements Incidence rate (1000× person-years: PY) of hip fracture in each group (TAP and non-TAP). Cox regression models to estimate adjusted risks (hazard ratio: HR). The hip fracture incidence rate was higher in TAP patients (5.83 vs 3.58 fractures per 1000 PY), and is higher in all strata according to sex, age and type of diagnosis. The risk of suffering a hip fracture was 60% higher (HR: 1.60 95% CI: 1.34-1.92) in the TAP group than in the non-TAP group. The risk was higher in the group with schizophrenia (HR: 3.57 95% CI: 1.75-7.30), followed by bipolar disorder (HR: 2.61; 95% CI: 1.39-4.92) and depression (HR: 1.51; 95% CI: 1.21-1.88). Patients with antipsychotic treatment have a higher risk of hip fracture than those who have not been treated with antipsychotics.
ISSN:1578-1275
DOI:10.1016/j.aprim.2021.102171