Update on neuroendocrine tumors

Neuroendocrine Tumors (NETs) encompass a wide variety of tumors arising from neuroendocrine cells, which produce bioactive substances. The incidence of NETs increased significantly lately, becoming one of the most common tumors of the digestive tract. Their clinical presentation is as diverse as the...

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Bibliographic Details
Published in:Revista medíca de Chile 2021-06, Vol.149 (6), p.888
Main Authors: Carrillo, Diego, Muñoz-Medel, Matías, Retamal, Ignacio, Pinto, Mauricio, Bravo, María L, Nervi, Bruno, Peña, José, Valenzuela, Yasna, Guarda, Francisco J, Nilo, Flavia, Bello, Fernando, Orellana, Pilar, Vicentini, Daniel, Quintana, Juan Carlos, Torres, Paula J, Leal, José Luis, Garrido, Marcelo
Format: Article
Language:Spanish
Subjects:
Antineoplastic Agents - therapeutic use
Diarrhea
Humans
Neuroendocrine Tumors - diagnosis
Neuroendocrine Tumors - therapy
Somatostatin - therapeutic use
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Summary:Neuroendocrine Tumors (NETs) encompass a wide variety of tumors arising from neuroendocrine cells, which produce bioactive substances. The incidence of NETs increased significantly lately, becoming one of the most common tumors of the digestive tract. Their clinical presentation is as diverse as their capacity for hormone production. Carcinoid syndrome is the most common hormonal syndrome produced by NETs and is characterized by diarrhea, flushing and cardiac valvular lesions. New research brought multiple changes in the classification of these neoplasms and a new understanding about their diagnosis and treatment, promoting a multidisciplinary approach. Somatostatin analogues, radiation, biological, and cytotoxic drugs have improved the prognosis of these patients, which entails a great challenge for healthcare providers.
ISSN:0717-6163