Predictive value of the sFlt-1/PlGF ratio for preeclampsia in twin pregnancies: a retrospective study

Objective: This study aimed to investigate the efficiency of the soluble Fms-like tyrosine kinase 1 (sFlt-1)/placental growth factor (PlGF) ratio in predicting preeclampsia (PE) within 4 weeks in twin pregnancies. Methods: Seventy-eight women with serum angiogenic markers measured at 28 + 0 to 30 + ...

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Bibliographic Details
Published in:Hypertension in pregnancy 2021-10, Vol.40 (4), p.330-335
Main Authors: Shinohara, Satoshi, Sunami, Rei, Kasai, Mayuko, Yasuda, Genki, Uchida, Yuzo
Format: Article
Language:English
Subjects:
Adult
Biomarkers - blood
Female
fms-like tyrosine kinase-1
Humans
Placenta Growth Factor - blood
placental growth factor
Pre-Eclampsia - blood
Pre-Eclampsia - diagnosis
predicting factor
Predictive Value of Tests
preeclampsia
Pregnancy
Pregnancy Outcome - epidemiology
Pregnancy, Twin - blood
Retrospective Studies
Twin pregnancy
Vascular Endothelial Growth Factor Receptor-1 - blood
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Summary:Objective: This study aimed to investigate the efficiency of the soluble Fms-like tyrosine kinase 1 (sFlt-1)/placental growth factor (PlGF) ratio in predicting preeclampsia (PE) within 4 weeks in twin pregnancies. Methods: Seventy-eight women with serum angiogenic markers measured at 28 + 0 to 30 + 6 weeks of gestation were enrolled. A receiver-operating characteristic curve was used to determine the sFlt-1/PlGF ratio threshold to predict PE. Results: A cutoff value for the sFlt-1/PlGF ratio of 22.2 predicted PE presence within 4 weeks. Conclusion: An sFlt-1/PlGF ratio of ≤22.2 is potentially indicative of PE absence within 4 weeks in twin pregnancies.
ISSN:1064-1955
1525-6065
DOI:10.1080/10641955.2021.1987455