The immunoenhancement effects of sea buckthorn pulp oil in cyclophosphamide-induced immunosuppressed mice

In this study, the immunomodulatory effect of sea buckthorn (SBT) pulp oil was elucidated in immunosuppressed Balb/c mice induced by cyclophosphamide (CTX). The results showed that SBT pulp oil could reverse the decreasing trend of body weight, thymus/spleen index and hematological parameters induce...

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Bibliographic Details
Published in:Food & function 2021-09, Vol.12 (17), p.7954-7963
Main Authors: Zhang, Jin, Zhou, Hong-Chang, He, Shuai-Bing, Zhang, Xiu-Fang, Ling, Yu-Hang, Li, Xiao-Yu, Zhang, Hui, Hou, Dian-Dong
Format: Article
Language:English
Subjects:
Abundance
Animals
Body weight
Composition
Cyclophosphamide
Cyclophosphamide - adverse effects
Cytotoxicity
Fatty acids
Female
Flora
Gastrointestinal Microbiome - drug effects
Hippophae - chemistry
Humans
Immune response
Immune system
Immunocompromised Host - drug effects
Immunoglobulin A
Immunomodulating Agents - administration & dosage
Immunomodulation
Immunomodulators
Immunosuppressive Agents - adverse effects
Inflammation - drug therapy
Inflammation - etiology
Inflammation - immunology
Interleukin 12
Interleukin 2
Interleukin 4
Intestinal microflora
Intestinal Mucosa - drug effects
Intestinal Mucosa - microbiology
Intestine
Lymph nodes
Lymphocytes
Lymphocytes T
Macrophages
Mice
Mice, Inbred BALB C
Microbiota
Mucosa
Oil
Phagocytosis
Plant Oils - administration & dosage
Probiotics
Spleen
Toxicity
Tumor necrosis factor-α
γ-Interferon
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Summary:In this study, the immunomodulatory effect of sea buckthorn (SBT) pulp oil was elucidated in immunosuppressed Balb/c mice induced by cyclophosphamide (CTX). The results showed that SBT pulp oil could reverse the decreasing trend of body weight, thymus/spleen index and hematological parameters induced by CTX. Compared with immunosuppressive mice induced by CTX, SBT pulp oil could enhance NK cytotoxicity, macrophage phagocytosis, and T lymphocyte proliferation, and regulate the proportion of T cell subsets in mesenteric lymph nodes (MLN), and promote the production of secretory immunoglobulin A (sIgA), IFN-γ, IL-2, IL-4, IL-12 and TNF-α in the intestines. In addition, SBT pulp oil can promote the production of short fatty acids (SCFAs), increase the diversity of gut microbiota, improve the composition of intestinal flora, increase the abundance of Alistipes , Bacteroide s, Anaerotruncus , Lactobacillus , ASF356 , and Roseburia , while decreasing the abundance of Mucispirillum, Anaeroplasma, Pelagibacterium, Brevundimonas, Ochrobactrum, Acinetobacter, Ruminiclostridium, Blautia, Ruminiclostridium, Oscillibacter , and Faecalibaculum . This study shows that SBT pulp oil can regulate the diversity and composition of intestinal microflora in CTX-induced immunosuppressive Balb/c mice, thus enhancing the intestinal mucosa and systemic immune response. The results can provide a basis for understanding the function of SBT pulp oil and its application as a new probiotic and immunomodulator. This study shows that SBT pulp oil can promote the concentrations of SCFAs and regulate the diversity and composition of intestinal microflora in CTX-induced immunosuppressive BALB/c mice, thus enhancing the intestinal mucosa and systemic immune functions.
ISSN:2042-6496
2042-650X
DOI:10.1039/d1fo01257f