Corneal Crosslinking Biomechanics Evaluated by a Novel and Easily Implemented Differential Tonometry Method

Purpose: Evaluate potential corneal biomechanical changes following corneal crosslinking (CXL) by paired differential tonometry intraocular pressure (IOP) measurements with a Goldmann tonometer (GAT) prism and corneal compensating, correcting applanation tonometry surface (CATS) prism. Methods: IOP...

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Bibliographic Details
Published in:Current eye research 2021-11, Vol.46 (11), p.1614-1620
Main Authors: Wang, Mingwu, Berdahl, John, McCafferty, Sean
Format: Article
Language:English
Subjects:
Adult
Biomechanical Phenomena
Cornea - drug effects
Cornea - physiology
corneal biomechanics
corneal crosslinking
corneal hysteresis
Corneal Pachymetry
Cross-Linking Reagents - therapeutic use
Elastic Modulus - physiology
Female
glaucoma
Humans
Intraocular Pressure - physiology
keratoconus
Keratoconus - drug therapy
Keratoconus - physiopathology
Male
Photochemotherapy - methods
Photosensitizing Agents - therapeutic use
Prospective Studies
Riboflavin - therapeutic use
Tonometry
Tonometry, Ocular - methods
Ultraviolet Rays
Young Adult
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Summary:Purpose: Evaluate potential corneal biomechanical changes following corneal crosslinking (CXL) by paired differential tonometry intraocular pressure (IOP) measurements with a Goldmann tonometer (GAT) prism and corneal compensating, correcting applanation tonometry surface (CATS) prism. Methods: IOP was measured prospectively on 23 unique eyes undergoing CXL for keratoconus with a GAT using a standard flat GAT prism and a curved corneal error correcting CATS prism before treatment and at 2 weeks, 2 months and 6 months after treatment. Concurrent measurements of central corneal thickness (CCT) and corneal hysteresis (CH) were completed. Results: Paired IOP measurements with standard GAT and corneal correcting CATS prisms indicated a significant sustained relative increase in the differential IOP between the two prisms after CXL (p = .002,0.051,0.062). CH initially decreased at two weeks post-CXL then returned to sustained pre-op levels (p = .033,0.20,0.20). CCT progressively decreased following CXL (p = .005). Discussion: Differential tonometry between standard GAT and corneal biomechanical compensating CATS prisms indicates findings consistent with increased corneal rigidity following CXL and may demonstrate a simple and sensitive method for measurement of relative corneal biomechanical changes due to pharmacologic agents and procedures.
ISSN:0271-3683
1460-2202
DOI:10.1080/02713683.2021.1916039