Macrotricolorin A, a new diarylpropanoid from the Vietnamese plant Macrosolen tricolor (Lecomte) Danser

From the Vietnamese plant Macrosolen tricolor (Lecomte) Danser, one new diarylpropanoid, named macrotricolorin A (1) together with three diarylheptanoids including bisdemethoxycurcumin (2), demethoxycurcumin (3) and curcumin (4), were isolated. Their structures were elucidated by intensive analyses...

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Bibliographic Details
Published in:Natural product research 2022-01, Vol.36 (1), p.165-170
Main Authors: Le, Kieu Hung, Bui, Thi Kim Ngan, Pham, Nguyen Kim Tuyen, Dang, Van Son, Ngo, Trong Nghia, Phan, Nhat Minh, Bui, Trong Dat, Tran, Trong Duc, Nguyen, Quan Hien, Ngo, Quoc Luan, Mai, Dinh Tri, Nguyen, Tan Phat
Format: Article
Language:English
Subjects:
anti-inflammatory activity
Anti-Inflammatory Agents - pharmacology
Asians
diarylalkanoid
Humans
Lipopolysaccharides
Loranthaceae
Macrosolen tricolor
macrotricolorin A
Nitric Oxide
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Summary:From the Vietnamese plant Macrosolen tricolor (Lecomte) Danser, one new diarylpropanoid, named macrotricolorin A (1) together with three diarylheptanoids including bisdemethoxycurcumin (2), demethoxycurcumin (3) and curcumin (4), were isolated. Their structures were elucidated by intensive analyses of their IR, UV, HR-ESI-MS and NMR (1 D & 2 D) spectra. It is the first time that diarylalkanoids have been reported from the genus Macrosolen. Compound 1 exhibited anti-inflammatory activity against the nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW264.7 with an IC 50 value of 27.54 ± 1.75 μM.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2020.1771710