Effects of curcumin on the pharmacokinetics of amlodipine in rats and its potential mechanism

Hyperlipidaemia and hypertension are often treated together with curcumin and amlodipine. It is necessary to investigate the drug-drug interaction between curcumin and amlodipine. The interaction between curcumin and amlodipine was investigated in rats and with rat liver microsomes. The pharmacokine...

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Bibliographic Details
Published in:Pharmaceutical biology 2020-01, Vol.58 (1), p.465-468
Main Authors: Jiang, Na, Zhang, Meicheng, Meng, Xiangzhi, Sun, Bin
Format: Article
Language:English
Subjects:
Amlodipine - administration & dosage
Amlodipine - pharmacokinetics
Animals
Curcumin
Curcumin - administration & dosage
Curcumin - pharmacokinetics
CYP3A4
Drug interaction
Drug interactions
Drug Interactions - physiology
Drug-drug interaction
Hyperlipidemia
Liver
Male
metabolic stability
Metabolism
Microsomes
Microsomes, Liver - drug effects
Microsomes, Liver - metabolism
Pharmacokinetics
Rats
Rats, Sprague-Dawley
Rodents
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Summary:Hyperlipidaemia and hypertension are often treated together with curcumin and amlodipine. It is necessary to investigate the drug-drug interaction between curcumin and amlodipine. The interaction between curcumin and amlodipine was investigated in rats and with rat liver microsomes. The pharmacokinetics of amlodipine (1 mg/kg) was investigated in rats with or without curcumin pre-treatment (2 mg/kg), six rats in each group. The metabolic stability of amlodipine was investigated with rat liver microsomes. Curcumin significantly increased the C max (26.19 ± 2.21 versus 17.80 ± 1.56 μg/L), AUC (0-t) (507.27 ± 60.23 versus 238.68 ± 45.59 μg·h/L), and t 1/2 (14.69 ± 1.64 versus 11.43 ± 1.20 h) of amlodipine (p 
ISSN:1388-0209
1744-5116
DOI:10.1080/13880209.2020.1764060