Cu 2 O/PEDOT:PSS/ZnO Nanocomposite Material Biosensor for Esophageal Cancer Detection

A highly sensitive photoelectrochemical (PEC) biosensor without external bias was developed in this study. The biosensor was configured with a p-Cu O and n-ZnO heterostructure. Hexamethylenetetramine (HMTA) and poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) was used to improve th...

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Bibliographic Details
Published in:Sensors (Basel, Switzerland) Switzerland), 2020-04, Vol.20 (9)
Main Authors: Tseng, Kuang-Wen, Hsiao, Yu-Ping, Jen, Chun-Ping, Chang, Tsung-Shun, Wang, Hsiang-Chen
Format: Article
Language:English
Subjects:
Biosensing Techniques
Bridged Bicyclo Compounds, Heterocyclic - chemistry
Copper - chemistry
Esophageal Neoplasms - diagnosis
Humans
Nanocomposites - chemistry
Polymers - chemistry
Zinc Oxide - chemistry
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Summary:A highly sensitive photoelectrochemical (PEC) biosensor without external bias was developed in this study. The biosensor was configured with a p-Cu O and n-ZnO heterostructure. Hexamethylenetetramine (HMTA) and poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) was used to improve the crystal structure of Cu O and ZnO and reduce the defects in the Cu O/ZnO interface. This fabrication method provided the highly crystallized Cu O/ZnO structure with excellent electrical property and photoresponse in visible light. The structure was applied to a biosensor for detecting two different cancerous levels of esophageal cells, namely, OE21 and OE21-1, with a high gain in photocurrent (5.8 and 6.2 times, respectively) and a low detection limit (3000 cells in 50 μL). We believe that such a p-n heterojunction PEC biosensor could advance biosensor development and provide a promising candidate for biomedical applications.
ISSN:1424-8220