The Reproducibility of Global Electrical Heterogeneity ECG Measurements

Background: Global electrical heterogeneity (GEH) is a useful predictor of adverse clinical outcomes. However, reproducibility of GEH measurements on 10-second routine clinical ECG is unknown. Methods: Data of the prospective cohort study of incident hemodialysis patients (n=253; mean age 54.6±13.5y...

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Main Authors: Perez-Alday, Erick A., Hamilton, Christopher, Li-Pershing, Annabel, Monroy-Trujillo, Jose M, Estrella, Michelle, Sozio, Stephen M, Jaar, Bernard, Parekh, Rulan, Tereshchenko, Larisa
Format: Conference Proceeding
Language:English
Subjects:
Atmospheric measurements
Azimuth
Biomedical measurement
Electrocardiography
Heart beat
Particle measurements
Sociology
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Summary:Background: Global electrical heterogeneity (GEH) is a useful predictor of adverse clinical outcomes. However, reproducibility of GEH measurements on 10-second routine clinical ECG is unknown. Methods: Data of the prospective cohort study of incident hemodialysis patients (n=253; mean age 54.6±13.5y; 56% male; 79% African American) were analysed. Two random 10-second segments of 5-minute ECG recording in sinus rhythm were compared. GEH was measured as spatial QRS-T angle, spatial ventricular gradient (SVG) magnitude and direction (azimuth and elevation), and a scalar value of SVG measured by (1) sum absolute QRST integral (SAI QRST), and (2) QT integral on vector magnitude signal (iVM QT ). Bland-Altman analysis was used to calculate agreement. Results: For all studied vectorcardiographic metrics, agreement was substantial (Lin`s concordance coefficient >0.98), and precision was perfect (>99.99%). 95% limits of agreement were ±14 ° for spatial QRS-T angle, ±13 ° for SVG azimuth ±4 ° for SVG elevation, ±14 mV*ms for SVG magnitude, and ±17 mV*ms for SAI QRST. SAI QRST and iVM QT were in substantial agreement with each other. Conclusion: Reproducibility of a 10-second automated GEH ECG measurements was substantial, and precision was perfect.
ISSN:2325-8861
2325-887X
DOI:10.22489/CinC.2018.162