Co-stabilization of pioglitazone HCL nanoparticles prepared by planetary ball milling: in-vitro and in-vivo evaluation

Pioglitazone (PGZ) is an oral antidiabetic agent that increases cell resistance to insulin, thereby decreasing blood glucose levels. PGZ is a class II drug. Because of its pH-dependent solubility, it precipitates at the intestinal pH, resulting in an erratic and incomplete absorption following oral...

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Bibliographic Details

Published in:	Pharmaceutical development and technology 2020-08, Vol.25 (7), p.845-854
Main Authors:	Alshora, Doaa H., Alsaif, Shaikha, Ibrahim, Mohamed A., Ezzeldin, Essam, Almeanazel, Osaid T., Abou El Ela, Amal El Sayeh, Ashri, Lubna Y.
Format:	Article
Language:	eng
Subjects:	Animals ball milling Chemistry, Pharmaceutical - methods co-stabilizer Drug Evaluation, Preclinical - methods Drug Stability Hypoglycemic Agents - chemical synthesis Hypoglycemic Agents - pharmacokinetics Male nanoparticles Nanoparticles - chemistry Nanoparticles - metabolism pharmacokinetics Pioglitazone - chemical synthesis Pioglitazone - pharmacokinetics Pioglitazone HCl Random Allocation Rats Rats, Wistar X-Ray Diffraction - methods
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