Optimization of the radiolabelling method for improved in vitro and in vivo stability of 90 Y-albumin microspheres

Biologically stable Y-labelled albumin microspheres (AMS) were developed by optimizing the process of their preparation. Three formulations of Y-AMS were initially prepared with high radiolabelling yield but depending on the step when the radionuclide Y and DTPA chelator were added, radiolabelled mi...

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Bibliographic Details
Published in:Applied radiation and isotopes 2020-02, Vol.156, p.108984
Main Authors: Aleksandar, Vukadinović, Drina, Janković, Magdalena, Radović, Zorana, Milanović, Marija, Mirković, Dragana, Stanković, Sanja, Vranješ-Đurić
Format: Article
Language:English
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Summary:Biologically stable Y-labelled albumin microspheres (AMS) were developed by optimizing the process of their preparation. Three formulations of Y-AMS were initially prepared with high radiolabelling yield but depending on the step when the radionuclide Y and DTPA chelator were added, radiolabelled microspheres with different in vitro and in vivo stability were obtained. DTPA was proved as a useful chelating agent that tightly links radionuclide Y to albumin. Also, AMS radiolabelled via DTPA during preparation and before microspheres stabilization, showed significant in vitro and in vivo stability ready for the potential use in selective internal radiation therapy.
ISSN:1872-9800