Microwave ablation or plus monochemotherapy in elderly advanced non-small-cell lung cancer patients

To evaluate the efficacy of microwave ablation (MWA) and MWA plus monochemotherapy in elderly patients with advanced non-small-cell lung cancer (NSCLC). Patients with advanced NSCLC aged ≥70 years were retrospectively enrolled. MWA was performed at the primary tumor site. The end points included pro...

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Bibliographic Details
Published in:Minimally invasive therapy and allied technologies 2021-04, Vol.30 (2), p.106-114
Main Authors: Wei, Zhigang, Li, Qingyu, Ye, Xin, Yang, Xia, Huang, Guanghui, Li, Wenhong, Wang, Jiao, Han, Xiaoying
Format: Article
Language:English
Subjects:
Aged
Carcinoma, Non-Small-Cell Lung - drug therapy
Female
Humans
Lung Neoplasms - drug therapy
Male
microwave ablation
Microwaves
Non-small-cell lung cancer
overall survival
progression-free survival
Retrospective Studies
Treatment Outcome
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Summary:To evaluate the efficacy of microwave ablation (MWA) and MWA plus monochemotherapy in elderly patients with advanced non-small-cell lung cancer (NSCLC). Patients with advanced NSCLC aged ≥70 years were retrospectively enrolled. MWA was performed at the primary tumor site. The end points included progression-free survival (PFS), response to MWA and overall survival (OS). Fifty-four patients were enrolled; of these, 36 received monochemotherapy. Complete ablation was achieved in 42 patients (77.8%). The median PFS and OS were 4.9 months and 21.8 months, respectively. Univariate analyses showed that female patients had superior PFS (31.9 months [95% confidence interval (CI): 0.8-63.0]) vs. 5.0 months in male patients (95% CI: 2.0-8.0), p = .002). Female sex was associated with better OS (not reached vs. 10.8 months, 95% CI: 9.3-12.3, p = .003). Moreover, patients with primary tumor size
ISSN:1364-5706
1365-2931
DOI:10.1080/13645706.2019.1678173