A new anti-inflammatory flavonoid glycoside from tetraena aegyptia

The chromatographic reinvestigation the methanol extract of Tetraena aegyptia led to the separation of a new flavonoid glycoside, isorhamnetin-3-O-[2```,3```-O-isopropylidene-α-L-rhamnopyranosyl]-(1```→6``)-O-β-D-glucopyranoside (1), together with two known flavonoids, isorhamnetin (2) and isorhamne...

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Bibliographic Details
Published in:Natural product research 2021-06, Vol.35 (12), p.1985-1990
Main Authors: Zaki, Ahmed A., Xu, Xiaoqian, Wang, Yuewen, Shie, Pei-Hsin, Qiu, Longxin
Format: Article
Language:English
Subjects:
Anti-inflammatory
Anti-inflammatory agents
Cytokines
Enzyme-linked immunosorbent assay
Flavone glycosides
Flavonoids
Gene expression
Glycosides
Inflammation
Interleukin 6
Isorhamnetin
Lipopolysaccharides
RAW 264.7
Tetraena aegyptia
Tumor necrosis factor-α
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Summary:The chromatographic reinvestigation the methanol extract of Tetraena aegyptia led to the separation of a new flavonoid glycoside, isorhamnetin-3-O-[2```,3```-O-isopropylidene-α-L-rhamnopyranosyl]-(1```→6``)-O-β-D-glucopyranoside (1), together with two known flavonoids, isorhamnetin (2) and isorhamnetin-3-O-glucoside (3), isolated for the first time from the plant. The new compound was evaluated for the anti-inflammatory activity by using LPS-induce RAW 264.7 cells model. Compound 1 showed significant inhibitory effect on NO release. ELISA assay showed a pronounced effect of 1 on the secretion of cytokines IL-6 and TNF-α, in a dose-dependent manner. Consistent results were obtained by qRT-PCR which revealed that compound 1 markedly reduced the mRNA expression of IL-6 and TNF-α. Together these data, we demonstrated the anti-inflammatory activity of compound 1.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2019.1650356