Sarcopenia

Sarcopenia

Sarcopenia is a progressive and generalised skeletal muscle disorder involving the accelerated loss of muscle mass and function that is associated with increased adverse outcomes including falls, functional decline, frailty, and mortality. It occurs commonly as an age-related process in older people...

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Bibliographic Details
Published in:The Lancet (British edition) 2019-06, Vol.393 (10191), p.2636-2646
Main Authors: Cruz-Jentoft, Alfonso J, Sayer, Avan A
Format: Article
Language:eng
Subjects:
Arthritis
Biomarkers
Clinical medicine
Diagnosis
Disease
Drug development
Frailty
Mortality
Muscle function
Muscles
Musculoskeletal system
Nutrition
Obesity
Older people
Osteoporosis
Prevention
Risk analysis
Risk factors
Sarcopenia
Seminars
Skeletal muscle
Weight control
Working groups
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Summary:Sarcopenia is a progressive and generalised skeletal muscle disorder involving the accelerated loss of muscle mass and function that is associated with increased adverse outcomes including falls, functional decline, frailty, and mortality. It occurs commonly as an age-related process in older people, influenced not only by contemporaneous risk factors, but also by genetic and lifestyle factors operating across the life course. It can also occur in mid-life in association with a range of conditions. Sarcopenia has become the focus of intense research aiming to translate current knowledge about its pathophysiology into improved diagnosis and treatment, with particular interest in the development of biomarkers, nutritional interventions, and drugs to augment the beneficial effects of resistance exercise. Designing effective preventive strategies that people can apply during their lifetime is of primary concern. Diagnosis, treatment, and prevention of sarcopenia is likely to become part of routine clinical practice.
ISSN:0140-6736
1474-547X