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A new sesquiterpenoid with cytotoxic and anti-inflammatory activity from the leaves of Datura metel L
A new sesquiterpenoid glycoside, consisting of one vetispirane-type, dmetelisproside A (1), together with two known megastigmane sesquiterpenoids, citroside A (2) and staphylionoside D (3) were isolated from the leaves of Datura metel L. The structures were determined by analysis of their MS and NMR...
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| Published in: | Natural product research 2021-02, Vol.35 (4), p.607-613 |
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| Main Authors: | , , , , , |
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| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c441t-546fcc0b62f8b063ba9ad31df75050edef89315d0470ef0fd6f355fa4a7159003 |
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| cites | cdi_FETCH-LOGICAL-c441t-546fcc0b62f8b063ba9ad31df75050edef89315d0470ef0fd6f355fa4a7159003 |
| container_end_page | 613 |
| container_issue | 4 |
| container_start_page | 607 |
| container_title | Natural product research |
| container_volume | 35 |
| creator | Guo, Rui Liu, Yan Pan, Juan Guan, Wei Yang, Bing-You Kuang, Hai-Xue |
| description | A new sesquiterpenoid glycoside, consisting of one vetispirane-type, dmetelisproside A (1), together with two known megastigmane sesquiterpenoids, citroside A (2) and staphylionoside D (3) were isolated from the leaves of Datura metel L. The structures were determined by analysis of their MS and NMR data as well as by comparison with literature values. All isolates were evaluated for cytotoxicity toward SGC-7901, Hepg2, HeLa, MCF-7, and MDA-MB-231 cancer cell lines, and anti-inflammatory activity against nitric oxide (NO) in RAW 264.7 cells in vitro. Compounds 1 and 2 exhibited pronounced cytotoxicity against SGC-7901 and HeLa cells with IC
50
values in the range of 21.43 to 29.51 μm. All three compounds displayed potential effects against NO production with IC
50
values of 31.10, 34.25, and 44.31 μm, respectively. Thus, these isolated compounds in the leaves of Datura metel L were subjected to bioactivity substances for future studies on medicinal application. |
| doi_str_mv | 10.1080/14786419.2019.1590715 |
| format | article |
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50
values in the range of 21.43 to 29.51 μm. All three compounds displayed potential effects against NO production with IC
50
values of 31.10, 34.25, and 44.31 μm, respectively. Thus, these isolated compounds in the leaves of Datura metel L were subjected to bioactivity substances for future studies on medicinal application.</description><identifier>ISSN: 1478-6419</identifier><identifier>EISSN: 1478-6427</identifier><identifier>DOI: 10.1080/14786419.2019.1590715</identifier><identifier>PMID: 30919660</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Animals ; anti-inflammatory activity ; Anti-inflammatory agents ; Anti-Inflammatory Agents - chemistry ; Anti-Inflammatory Agents - pharmacology ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacology ; Biocompatibility ; Biological activity ; Cell Death - drug effects ; Cell Line, Tumor ; Cytotoxicity ; Datura metel ; Datura metel - chemistry ; Humans ; Inflammation ; Leaves of Datura metel L ; Mice ; Nitric oxide ; Nitric Oxide - metabolism ; NMR ; Nuclear magnetic resonance ; Plant Leaves - chemistry ; RAW 264.7 Cells ; Sesquiterpenes - chemistry ; Sesquiterpenes - pharmacology ; sesquiterpenoid ; Sesquiterpenoids ; solanaceae ; Toxicity ; Tumor cell lines</subject><ispartof>Natural product research, 2021-02, Vol.35 (4), p.607-613</ispartof><rights>2019 Informa UK Limited, trading as Taylor & Francis Group 2019</rights><rights>2019 Informa UK Limited, trading as Taylor & Francis Group</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-546fcc0b62f8b063ba9ad31df75050edef89315d0470ef0fd6f355fa4a7159003</citedby><cites>FETCH-LOGICAL-c441t-546fcc0b62f8b063ba9ad31df75050edef89315d0470ef0fd6f355fa4a7159003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30919660$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guo, Rui</creatorcontrib><creatorcontrib>Liu, Yan</creatorcontrib><creatorcontrib>Pan, Juan</creatorcontrib><creatorcontrib>Guan, Wei</creatorcontrib><creatorcontrib>Yang, Bing-You</creatorcontrib><creatorcontrib>Kuang, Hai-Xue</creatorcontrib><title>A new sesquiterpenoid with cytotoxic and anti-inflammatory activity from the leaves of Datura metel L</title><title>Natural product research</title><addtitle>Nat Prod Res</addtitle><description>A new sesquiterpenoid glycoside, consisting of one vetispirane-type, dmetelisproside A (1), together with two known megastigmane sesquiterpenoids, citroside A (2) and staphylionoside D (3) were isolated from the leaves of Datura metel L. The structures were determined by analysis of their MS and NMR data as well as by comparison with literature values. All isolates were evaluated for cytotoxicity toward SGC-7901, Hepg2, HeLa, MCF-7, and MDA-MB-231 cancer cell lines, and anti-inflammatory activity against nitric oxide (NO) in RAW 264.7 cells in vitro. Compounds 1 and 2 exhibited pronounced cytotoxicity against SGC-7901 and HeLa cells with IC
50
values in the range of 21.43 to 29.51 μm. All three compounds displayed potential effects against NO production with IC
50
values of 31.10, 34.25, and 44.31 μm, respectively. Thus, these isolated compounds in the leaves of Datura metel L were subjected to bioactivity substances for future studies on medicinal application.</description><subject>Animals</subject><subject>anti-inflammatory activity</subject><subject>Anti-inflammatory agents</subject><subject>Anti-Inflammatory Agents - chemistry</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Biocompatibility</subject><subject>Biological activity</subject><subject>Cell Death - drug effects</subject><subject>Cell Line, Tumor</subject><subject>Cytotoxicity</subject><subject>Datura metel</subject><subject>Datura metel - chemistry</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Leaves of Datura metel L</subject><subject>Mice</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - metabolism</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Plant Leaves - chemistry</subject><subject>RAW 264.7 Cells</subject><subject>Sesquiterpenes - chemistry</subject><subject>Sesquiterpenes - pharmacology</subject><subject>sesquiterpenoid</subject><subject>Sesquiterpenoids</subject><subject>solanaceae</subject><subject>Toxicity</subject><subject>Tumor cell lines</subject><issn>1478-6419</issn><issn>1478-6427</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kU9v3CAQxVHVqvnTfoRWSL3k4mSwAZtbozRpI63US3tGLAwKkW02gLP1t6-t3eTQQw8MaPSbN-g9Qj4xuGTQwRXjbSc5U5c1LIUJBS0Tb8jp2q8kr9u3r2-mTshZzo8ANRNCvCcnDSimpIRTgtd0xD3NmJ-mUDDtcIzB0X0oD9TOJZb4J1hqRrecEqow-t4MgykxzdTYEp5DmalPcaDlAWmP5hkzjZ5-M2VKhg5YsKebD-SdN33Gj8f7nPy-u_1186Pa_Px-f3O9qSznrFSCS28tbGXtuy3IZmuUcQ1zvhUgAB36TjVMOOAtoAfvpG-E8IabdjUAmnNycdDdpfg0YS56CNli35sR45R1zZRiXVc37YJ--Qd9jFMal9_pmndcqk6qVVAcKJtizgm93qUwmDRrBnrNQb_koNcc9DGHZe7zUX3aDuhep16MX4CvB2BxNKbB7GPqnS5m7mPyyYw2ZN38f8df03-XdA</recordid><startdate>20210216</startdate><enddate>20210216</enddate><creator>Guo, Rui</creator><creator>Liu, Yan</creator><creator>Pan, Juan</creator><creator>Guan, Wei</creator><creator>Yang, Bing-You</creator><creator>Kuang, Hai-Xue</creator><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20210216</creationdate><title>A new sesquiterpenoid with cytotoxic and anti-inflammatory activity from the leaves of Datura metel L</title><author>Guo, Rui ; Liu, Yan ; Pan, Juan ; Guan, Wei ; Yang, Bing-You ; Kuang, Hai-Xue</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-546fcc0b62f8b063ba9ad31df75050edef89315d0470ef0fd6f355fa4a7159003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>anti-inflammatory activity</topic><topic>Anti-inflammatory agents</topic><topic>Anti-Inflammatory Agents - chemistry</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Biocompatibility</topic><topic>Biological activity</topic><topic>Cell Death - drug effects</topic><topic>Cell Line, Tumor</topic><topic>Cytotoxicity</topic><topic>Datura metel</topic><topic>Datura metel - chemistry</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Leaves of Datura metel L</topic><topic>Mice</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - metabolism</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Plant Leaves - chemistry</topic><topic>RAW 264.7 Cells</topic><topic>Sesquiterpenes - chemistry</topic><topic>Sesquiterpenes - pharmacology</topic><topic>sesquiterpenoid</topic><topic>Sesquiterpenoids</topic><topic>solanaceae</topic><topic>Toxicity</topic><topic>Tumor cell lines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guo, Rui</creatorcontrib><creatorcontrib>Liu, Yan</creatorcontrib><creatorcontrib>Pan, Juan</creatorcontrib><creatorcontrib>Guan, Wei</creatorcontrib><creatorcontrib>Yang, Bing-You</creatorcontrib><creatorcontrib>Kuang, Hai-Xue</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Natural product research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guo, Rui</au><au>Liu, Yan</au><au>Pan, Juan</au><au>Guan, Wei</au><au>Yang, Bing-You</au><au>Kuang, Hai-Xue</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A new sesquiterpenoid with cytotoxic and anti-inflammatory activity from the leaves of Datura metel L</atitle><jtitle>Natural product research</jtitle><addtitle>Nat Prod Res</addtitle><date>2021-02-16</date><risdate>2021</risdate><volume>35</volume><issue>4</issue><spage>607</spage><epage>613</epage><pages>607-613</pages><issn>1478-6419</issn><eissn>1478-6427</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>A new sesquiterpenoid glycoside, consisting of one vetispirane-type, dmetelisproside A (1), together with two known megastigmane sesquiterpenoids, citroside A (2) and staphylionoside D (3) were isolated from the leaves of Datura metel L. The structures were determined by analysis of their MS and NMR data as well as by comparison with literature values. All isolates were evaluated for cytotoxicity toward SGC-7901, Hepg2, HeLa, MCF-7, and MDA-MB-231 cancer cell lines, and anti-inflammatory activity against nitric oxide (NO) in RAW 264.7 cells in vitro. Compounds 1 and 2 exhibited pronounced cytotoxicity against SGC-7901 and HeLa cells with IC
50
values in the range of 21.43 to 29.51 μm. All three compounds displayed potential effects against NO production with IC
50
values of 31.10, 34.25, and 44.31 μm, respectively. Thus, these isolated compounds in the leaves of Datura metel L were subjected to bioactivity substances for future studies on medicinal application.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>30919660</pmid><doi>10.1080/14786419.2019.1590715</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Natural product research, 2021-02, Vol.35 (4), p.607-613 |
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| source | Taylor and Francis Science and Technology Collection |
| subjects | Animals anti-inflammatory activity Anti-inflammatory agents Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - pharmacology Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Biocompatibility Biological activity Cell Death - drug effects Cell Line, Tumor Cytotoxicity Datura metel Datura metel - chemistry Humans Inflammation Leaves of Datura metel L Mice Nitric oxide Nitric Oxide - metabolism NMR Nuclear magnetic resonance Plant Leaves - chemistry RAW 264.7 Cells Sesquiterpenes - chemistry Sesquiterpenes - pharmacology sesquiterpenoid Sesquiterpenoids solanaceae Toxicity Tumor cell lines |
| title | A new sesquiterpenoid with cytotoxic and anti-inflammatory activity from the leaves of Datura metel L |
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