A new sesquiterpenoid with cytotoxic and anti-inflammatory activity from the leaves of Datura metel L

A new sesquiterpenoid glycoside, consisting of one vetispirane-type, dmetelisproside A (1), together with two known megastigmane sesquiterpenoids, citroside A (2) and staphylionoside D (3) were isolated from the leaves of Datura metel L. The structures were determined by analysis of their MS and NMR...

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Bibliographic Details
Published in:Natural product research 2021-02, Vol.35 (4), p.607-613
Main Authors: Guo, Rui, Liu, Yan, Pan, Juan, Guan, Wei, Yang, Bing-You, Kuang, Hai-Xue
Format: Article
Language:English
Subjects:
Animals
anti-inflammatory activity
Anti-inflammatory agents
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - pharmacology
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Biocompatibility
Biological activity
Cell Death - drug effects
Cell Line, Tumor
Cytotoxicity
Datura metel
Datura metel - chemistry
Humans
Inflammation
Leaves of Datura metel L
Mice
Nitric oxide
Nitric Oxide - metabolism
NMR
Nuclear magnetic resonance
Plant Leaves - chemistry
RAW 264.7 Cells
Sesquiterpenes - chemistry
Sesquiterpenes - pharmacology
sesquiterpenoid
Sesquiterpenoids
solanaceae
Toxicity
Tumor cell lines
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Summary:A new sesquiterpenoid glycoside, consisting of one vetispirane-type, dmetelisproside A (1), together with two known megastigmane sesquiterpenoids, citroside A (2) and staphylionoside D (3) were isolated from the leaves of Datura metel L. The structures were determined by analysis of their MS and NMR data as well as by comparison with literature values. All isolates were evaluated for cytotoxicity toward SGC-7901, Hepg2, HeLa, MCF-7, and MDA-MB-231 cancer cell lines, and anti-inflammatory activity against nitric oxide (NO) in RAW 264.7 cells in vitro. Compounds 1 and 2 exhibited pronounced cytotoxicity against SGC-7901 and HeLa cells with IC 50 values in the range of 21.43 to 29.51 μm. All three compounds displayed potential effects against NO production with IC 50 values of 31.10, 34.25, and 44.31 μm, respectively. Thus, these isolated compounds in the leaves of Datura metel L were subjected to bioactivity substances for future studies on medicinal application.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2019.1590715