Toward 19 F magnetic resonance thermometry: spin-lattice and spin-spin-relaxation times and temperature dependence of fluorinated drugs at 9.4 T

This study examines the influence of the environmental factor temperature on the F NMR characteristics of fluorinated compounds in phantom studies and in tissue. F MR mapping and MR spectroscopy techniques were used to characterize the F NMR characteristics of perfluoro-crown ether (PFCE), isofluran...

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Bibliographic Details
Published in:Magma (New York, N.Y.) N.Y.), 2019-02, Vol.32 (1), p.51
Main Authors: Prinz, Christian, Delgado, Paula Ramos, Eigentler, Thomas Wilhelm, Starke, Ludger, Niendorf, Thoralf, Waiczies, Sonia
Format: Article
Language:English
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Summary:This study examines the influence of the environmental factor temperature on the F NMR characteristics of fluorinated compounds in phantom studies and in tissue. F MR mapping and MR spectroscopy techniques were used to characterize the F NMR characteristics of perfluoro-crown ether (PFCE), isoflurane, teriflunomide, and flupentixol. T and T mapping were performed, while temperature in the samples was changed (T = 20-60 °C) and monitored using fiber optic measurements. In tissue, T of PFCE nanoparticles was determined at physiological temperatures and compared with the T measured at room temperature. Studies on PFCE, isoflurane, teriflunomide, and flupentixol showed a relationship between temperature and their physicochemical characteristics, namely, chemical shift, T and T . T of PFCE nanoparticles was higher at physiological body temperatures compared to room temperature. The impact of temperature on the F NMR parameters of fluorinated compounds demonstrated in this study not only opens a trajectory toward F MR-based thermometry, but also indicates the need for adapting MR sequence parameters according to environmental changes such as temperature. This will be an absolute requirement for detecting fluorinated compounds by F MR techniques in vivo.
ISSN:1352-8661