C 60 fullerene and its nanocomplexes with anticancer drugs modulate circulating phagocyte functions and dramatically increase ROS generation in transformed monocytes

C fullerene-based nanoformulations are proposed to have a direct toxic effect on tumor cells. Previous investigations demonstrated that C fullerene used alone or being conjugated with chemotherapeutic agents possesses a potent anticancer activity. The main aim of this study was to investigate the ef...

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Published in:Cancer nanotechnology 2018-12, Vol.9 (1), p.8
Main Authors: Skivka, Larysa M, Prylutska, Svitlana V, Rudyk, Mariia P, Khranovska, Nataliia M, Opeida, Ievgeniia V, Hurmach, Vasyl V, Prylutskyy, Yuriy I, Sukhodub, Leonid F, Ritter, Uwe
Format: Article
Language:English
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Summary:C fullerene-based nanoformulations are proposed to have a direct toxic effect on tumor cells. Previous investigations demonstrated that C fullerene used alone or being conjugated with chemotherapeutic agents possesses a potent anticancer activity. The main aim of this study was to investigate the effect of C fullerene and its nanocomplexes with anticancer drugs on human phagocyte metabolic profile in vitro. Analysis of the metabolic profile of phagocytes exposed to C fullerene in vitro revealed augmented phagocytic activity and down-regulated reactive nitrogen species generation in these cells. Additionally, cytofluorimetric analysis showed that C fullerene can exert direct cytotoxic effect on normal and transformed phagocytes through the vigorous induction of intracellular reactive oxygen species generation. Cytotoxic action as well as the pro-oxidant effect of C fullerene was more pronounced toward malignant phagocytes. At the same time, C fullerenes have the ability to down-regulate the pro-oxidant effect of cisplatin on normal cells. These results indicate that C fullerenes may influence phagocyte metabolism and have both pro-oxidant and antioxidant properties. The antineoplastic effect of C fullerene has been observed by direct toxic effect on tumor cells, as well as through the modulation of the functions of effector cells of antitumor immunity.
ISSN:1868-6958
1868-6966
DOI:10.1186/s12645-017-0034-0