Correlation between CD4 + CD28 null T lymphocytes, regulatory T cells and plaque rupture: An Optical Coherence Tomography study in Acute Coronary Syndromes

A sizeable proportion of patients with Acute Coronary Syndromes (ACS) shows a unique adaptive immune system profile, associated to a worse outcome, characterized by higher CD4 CD28 T-cells, lower regulatory T-cells (Treg) and increased CD4 CD28 /Treg ratio. We sought to investigate the correlation b...

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Bibliographic Details
Published in:International journal of cardiology 2019-02, Vol.276, p.289
Main Authors: Ruggio, Aureliano, Pedicino, Daniela, Flego, Davide, Vergallo, Rocco, Severino, Anna, Lucci, Claudia, Niccoli, Giampaolo, Trani, Carlo, Burzotta, Francesco, Aurigemma, Cristina, Leone, Antonio Maria, Buffon, Antonino, D'Aiello, Alessia, Biasucci, Luigi Marzio, Crea, Filippo, Liuzzo, Giovanna
Format: Article
Language:English
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Summary:A sizeable proportion of patients with Acute Coronary Syndromes (ACS) shows a unique adaptive immune system profile, associated to a worse outcome, characterized by higher CD4 CD28 T-cells, lower regulatory T-cells (Treg) and increased CD4 CD28 /Treg ratio. We sought to investigate the correlation between CD4 CD28 T-cells, Treg, CD4 CD28 /Treg ratio and plaque phenotype as assessed by Optical Coherence Tomography (OCT). Peripheral blood mononuclear cells (PBMC) were collected from 30 Non-ST Elevation Myocardial Infarction (NSTEMI) patients, sub-grouped according to OCT analysis of culprit lesions into two cohorts: Ruptured Fibrous Cap (NSTEMI-RFC, n = 12) and Intact Fibrous Cap (NSTEMI-IFC, n = 18). Stable Angina patients (SA, n = 18) were used as controls. We examined the frequency of CD4 CD28 and Treg (defined as CD4 CD25 CD127 Foxp3 T-cells) by flow-cytometry. CD4 CD28 frequency (median, range) was significantly higher in NSTEMI-RFC patients (17.3%, 12.5-33.8) as compared with NSTEMI-IFC (3.8%, 0.3-14.1) and SA (3%, 0.6-17.7) (P 
ISSN:1874-1754