Limitations on estimation of effective scatterer diameters

The influence of spatial diversity in acoustic scattering properties on estimates of the effective scatterer diameter (ESD) applied to soft biological tissues is investigated. This study is based on two-dimensional simulations of scattering media, beginning with random distributions of simple disk s...

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Bibliographic Details
Published in:The Journal of the Acoustical Society of America 2017-12, Vol.142 (6), p.3677-3690
Main Authors: Zhu, Yang, Han, Aiguo, O'Brien, William D., Oelze, Michael L., Insana, Michael F.
Format: Article
Language:English
Subjects:
Biomedical Acoustics
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Summary:The influence of spatial diversity in acoustic scattering properties on estimates of the effective scatterer diameter (ESD) applied to soft biological tissues is investigated. This study is based on two-dimensional simulations of scattering media, beginning with random distributions of simple disk structures where all scattering features are known exactly. It concludes with an analysis of histology maps from healthy and fatty rabbit liver. Further, the liver histology is decomposed using an orthonormal basis to separate acoustic scattering at various spatial scales and observe how it influences ESD estimates. Overall, the goal is to quantitatively interpret ESD results for diagnostic assessments despite wide variations in tissue scatterer properties.
ISSN:0001-4966
1520-8524
DOI:10.1121/1.5017602