Static and dynamic 18 F-FET PET for the characterization of gliomas defined by IDH and 1p/19q status

The molecular features isocitrate dehydrogenase (IDH) mutation and 1p/19q co-deletion have gained major importance for both glioma typing and prognosis and have, therefore, been integrated in the World Health Organization (WHO) classification in 2016. The aim of this study was to characterize static...

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Bibliographic Details
Published in:European journal of nuclear medicine and molecular imaging 2018-03, Vol.45 (3), p.443
Main Authors: Verger, Antoine, Stoffels, Gabriele, Bauer, Elena K, Lohmann, Philipp, Blau, Tobias, Fink, Gereon R, Neumaier, Bernd, Shah, Nadim J, Langen, Karl-Josef, Galldiks, Norbert
Format: Article
Language:English
Subjects:
Adult
Brain Neoplasms - diagnostic imaging
Brain Neoplasms - enzymology
Brain Neoplasms - genetics
Chromosome Deletion
Chromosomes, Human, Pair 1 - genetics
Chromosomes, Human, Pair 19 - genetics
Female
Glioma - diagnostic imaging
Glioma - enzymology
Glioma - genetics
Humans
Isocitrate Dehydrogenase - genetics
Male
Middle Aged
Positron-Emission Tomography
Prognosis
Retrospective Studies
Tyrosine - analogs & derivatives
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Summary:The molecular features isocitrate dehydrogenase (IDH) mutation and 1p/19q co-deletion have gained major importance for both glioma typing and prognosis and have, therefore, been integrated in the World Health Organization (WHO) classification in 2016. The aim of this study was to characterize static and dynamic O-(2- F-fluoroethyl)-L-tyrosine ( F-FET) PET parameters in gliomas with or without IDH mutation or 1p/19q co-deletion. Ninety patients with newly diagnosed and untreated gliomas with a static and dynamic F-FET PET scan prior to evaluation of tumor tissue according to the 2016 WHO classification were identified retrospectively. Mean and maximum tumor-to-brain ratios (TBR ), as well as dynamic parameters (time-to-peak and slope) of F-FET uptake were calculated. Sixteen (18%) oligodendrogliomas (IDH mutated, 1p/19q co-deleted), 27 (30%) astrocytomas (IDH mutated only), and 47 (52%) glioblastomas (IDH wild type only) were identified. TBR , TBR , TTP and slope discriminated between IDH mutated astrocytomas and IDH wild type glioblastomas (P 
ISSN:1619-7089