Characterizing patients with multiple chromosomal aberrations detected by FISH in chronic lymphocytic leukemia

We analyzed the features of chronic lymphocytic leukemia (CLL) with multiple abnormalities (MA) detected by FISH. A local database including 2095 CLL cases was used and 323 with MA (15.4%) were selected. MA was defined by the presence of two or more alterations (deletions of 13q14 (13q-), 11q22 (11q...

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Bibliographic Details
Published in:Leukemia & lymphoma 2018-03, Vol.59 (3), p.633-642
Main Authors: González-Gascón y Marín, Isabel, Hernández-Sanchez, María, Rodríguez-Vicente, Ana Eugenia, Puiggros, Anna, Collado, Rosa, Luño, Elisa, González, Teresa, Ruiz-Xivillé, Neus, Ortega, Margarita, Gimeno, Eva, Muñoz, Carolina, Infante, Maria Stefania, Delgado, Julio, Vargas, María Teresa, González, Marcos, Bosch, Francesc, Espinet, Blanca, Hernández-Rivas, Jesús María, Hernández, José Ángel
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Chromosome Aberrations
Chromosomes, Human, Pair 11 - genetics
Chromosomes, Human, Pair 12 - genetics
Chromosomes, Human, Pair 13 - genetics
Chronic lymphocytic leukemia
multiple abnormalities
prognosis
fluorescence in-situ hybridization
Female
Follow-Up Studies
Humans
In Situ Hybridization, Fluorescence - methods
Leukemia, Lymphocytic, Chronic, B-Cell - genetics
Leukemia, Lymphocytic, Chronic, B-Cell - pathology
Male
Middle Aged
Prognosis
Retrospective Studies
Survival Rate
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Summary:We analyzed the features of chronic lymphocytic leukemia (CLL) with multiple abnormalities (MA) detected by FISH. A local database including 2095 CLL cases was used and 323 with MA (15.4%) were selected. MA was defined by the presence of two or more alterations (deletions of 13q14 (13q-), 11q22 (11q-), 17p13 (17p-) or trisomy 12 (+12)). The combination of 13q- with 11q- and 13q- with 17p-, accounted for 58.2% of the series, in contrast to 11q- with 17p- (3.7%). Patients carrying MA since diagnosis presented a short time to first therapy(TTFT) (27 months) and overall survival (OS) (76 months). The combinations including 17p- had a shorter OS (58 months) than the ones without 17p- (not reached, p = .002). Patients with a complex-FISH were the ones with worse OS (34 months). MA imply poor prognosis when they emerge at diagnosis, probably due to the high incidence of bad prognosis markers, which may be a reflection of a more complex karyotype.
ISSN:1042-8194
1029-2403
DOI:10.1080/10428194.2017.1349901