Impact of Aberrant Myeloid Antigen Expression on Outcomes of Patients with T-Cell Acute Lymphoblastic Leukemia

Objectives: To evaluate the impact of myeloid antigen expression on complete remission (CR), event-free survival (EFS), and overall survival (OS) in patients with T-cell acute lymphoblastic leukemia (T-ALL) treated with intensive chemotherapy. Methods: We retrospectively reviewed consecutive patient...

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Bibliographic Details
Published in:Oman medical journal 2017-05, Vol.32 (3), p.189-193
Main Authors: Al-Muslahi , Muhanna, Al-Huneini , Mohammed, Al-Khabori , Murtadha, Fawaz , Naglaa, Al-Riyami , Marwa, Al-Zaabi , Mohamed, Al-Lamki , Sulayma, Alkindi , Salam
Format: Article
Language:English
Subjects:
ANTIGENS
BLOOD DISORDERS
Diagnosis
Immunophenotyping
LEUKEMIA
LYMPHOBLASTIC LEUKEMIA
LYMPHOCYTES
Myeloid
MYELOID LEUKEMIA
Original
Outcome assessment (Medical care)
Patient Outcome Assessment
PATIENTS
T-Lymphocytes
Treatment
إضطرابات الدم
اللمفاويات
اللوكيميا الجذعية اللمفية
اللوكيميا النخاعية
المرضى
المستضدات
سرطان الدم
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Summary:Objectives: To evaluate the impact of myeloid antigen expression on complete remission (CR), event-free survival (EFS), and overall survival (OS) in patients with T-cell acute lymphoblastic leukemia (T-ALL) treated with intensive chemotherapy. Methods: We retrospectively reviewed consecutive patients diagnosed with T-ALL and treated in Sultan Qaboos University Hospital and Royal Hospital in Oman between 2004 and 2010. The diagnosis of T-ALL was established using French-American-British classification or World Health Organization criteria. Patients were considered having myeloid antigen expression if they expressed CD13, CD33, or both (My+ and My–). Results: Of the 39 patients, 38 were included in the study (25 patients with My– and median age of 18.4 years, 13 patients with My+ and median age of 22.0 years). Median follow-up was 12 months. Thirty-two out of the total cohort were eligible for response-rate assessment. Twenty-nine patients (90.6%) achieved CR with one or two courses of chemotherapy with similar CR rates between the two groups (p = 0.880). Twenty-five percent (5/20) of the patients with My– required two courses of induction, whereas 58.3% (7/12) of My+ required two courses of induction and the difference was statistically significant (p = 0.040). In the multivariable analysis; age, gender, initial white blood cell count, central nervous system disease, and myeloid antigen expression were not statistically significant predictors of CR. The EFS and OS were similar between the My+ and My– groups p = 0.180 and p = 0.440, respectively. Conclusions: Patients with T-ALL with myeloid antigen expression need more courses of induction; however, rates of CR, EFS, and OS are not different from those without myeloid antigen expression. Larger prospective studies are required to confirm these findings
ISSN:1999-768X
2070-5204
DOI:10.5001/omj.2017.36