Alzheimer's disease Aβ 42 peptide induces an increase in Na,K-ATPase glutathionylation

We have shown that the inhibition of Na,K-ATPase during its long-term incubation with amyloid beta (Aβ ), an Alzheimer's disease protein, is caused by the change in the thiol redox status of cells leading to induction of glutathionylation α-subunit of Na,K-ATPase. To restore the activity of Na,...

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Bibliographic Details

Published in:	Doklady. Biochemistry and biophysics 2017-03, Vol.473 (1), p.114
Main Authors:	Lakunina, V A, Petrushanko, I Y, Burnysheva, K M, Mitkevich, V A, Makarov, A A
Format:	Article
Language:	English
Subjects:	Alzheimer Disease - metabolism Amyloid beta-Peptides - pharmacology Cell Line, Tumor Dose-Response Relationship, Drug Glutathione - metabolism Glutathione Disulfide - metabolism Humans Peptide Fragments - pharmacology Sodium-Potassium-Exchanging ATPase - metabolism
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