Impact of high fat/high salt diet on myocardial oxidative stress

Background: High fat high salt diet contributes to oxidative stress and cardiac diseases. Aims: To determine the impact of moderately high fat diet (HFD), high salt (HS) or their combination on blood pressure (Bp) and myocardial oxidants/antioxidants. Methods: Sprague Dawley rats were assigned into...

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Bibliographic Details
Published in:Clinical and experimental hypertension (1993) 2017-02, Vol.39 (2), p.126-132
Main Authors: Mayyas, Fadia, Alzoubi, Karem H., Al-Taleb, Zahraa
Format: Article
Language:English
Subjects:
Animals
Antioxidants - metabolism
Blood Glucose - drug effects
Blood Glucose - metabolism
Blood Pressure
Catalase - drug effects
Catalase - metabolism
Diet, High-Fat
Glutathione - drug effects
Glutathione - metabolism
Glutathione Peroxidase - drug effects
Glutathione Peroxidase - metabolism
Heart - drug effects
high fat
high salt
Hypertension - metabolism
Myocardium - metabolism
Obesity - drug therapy
oxidative stress
Oxidative Stress - drug effects
Random Allocation
Rats
Rats, Sprague-Dawley
Sodium Chloride, Dietary - pharmacology
Superoxide Dismutase - drug effects
Superoxide Dismutase - metabolism
Thiobarbituric Acid Reactive Substances - metabolism
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Summary:Background: High fat high salt diet contributes to oxidative stress and cardiac diseases. Aims: To determine the impact of moderately high fat diet (HFD), high salt (HS) or their combination on blood pressure (Bp) and myocardial oxidants/antioxidants. Methods: Sprague Dawley rats were assigned into four groups; conventional diet (control, 5% fat, 0.5% NaCl), HFD (25% fat, 0.5% NaCl), HS (5% fat, 8% NaCl), or combined diet (HFD+HS) for 10 weeks. Bp and cardiac oxidants and antioxidants were measured. Result: HFD, HS, and their combination didn't cause obesity or dyslipidemia. Both HS and combined diets resulted in an increase in the heart/body weight ratio accompanied by an increase in Bp. No changes were observed in levels of the glutathione (GSH) system or superoxide dismutase (SOD) activities. However, a significant decrease in TBARS levels was observed in the HFD and the combined diet with a parallel increase in catalase activity in all groups. Relative to HFD, the combined diet was associated with increases in GSH reductase/peroxidase and SOD activities. Conclusions: The lack of changes in the GSH system, the decrease in TBARS, and the increase in catalase activity suggest that normal hearts adapt compensatory mechanisms to prevent oxidative damage in response to HFD/and or HS.
ISSN:1064-1963
1525-6006
DOI:10.1080/10641963.2016.1226894