Phase shift between respiratory oscillations in cerebral blood flow velocity and arterial blood pressure

We aim to investigate whether phase shift between respiratory oscillations in cerebral blood flow velocity (CBFV) and arterial blood pressure (ABP) is associated with changes in cerebral autoregulation (CA) or reflects the mechano-elastic properties of the cerebrovascular bed. The relationships betw...

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Bibliographic Details
Published in:Physiological measurement 2017-02, Vol.38 (2), p.310-324
Main Authors: Uryga, Agnieszka, Placek, Micha M, Wachel, Pawe, Szczepa ski, Tomasz, Czosnyka, Marek, Kasprowicz, Magdalena
Format: Article
Language:English
Subjects:
Adolescent
Adult
Arterial Pressure - physiology
Brain - blood supply
Brain - metabolism
cerebral autoregulation
Cerebrovascular Circulation - physiology
Elasticity
Female
Homeostasis
Humans
Male
Respiration
respiratory rate
time constant of cerebral arterial bed
time-frequency phase shift
transcranial Doppler
Young Adult
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Summary:We aim to investigate whether phase shift between respiratory oscillations in cerebral blood flow velocity (CBFV) and arterial blood pressure (ABP) is associated with changes in cerebral autoregulation (CA) or reflects the mechano-elastic properties of the cerebrovascular bed. The relationships between respiratory phase shift and slow wave phase shift versus cerebrovascular time constant (the product of cerebrovascular resistance and compliance) and the index of CA (Mx) were analyzed during breathing at 6, 10, and 15 breaths min−1 in 39 volunteers. With increasing respiratory rate the time constant, Mx, and respiratory phase shift decreased, whereas slow wave phase shift increased. The time constant correlated moderately strongly with the respiratory phase shift (R  =  0.49, p ≪ 0.001) and did not correlate with the slow wave phase shift. The slow wave phase shift was significantly associated with Mx (R  =  −0.46, p ≪ 0.001). The respiratory phase shift more accurately reflects the mechano-elastic properties of the cerebrovascular bed, whereas CA is better described by the slow wave phase shift.
ISSN:0967-3334
1361-6579
DOI:10.1088/1361-6579/38/2/310