Arousal From Sleep and Sympathetic Excitation During Wakefulness

Arousal From Sleep and Sympathetic Excitation During Wakefulness

Obstructive apnea during sleep elevates the set point for efferent sympathetic outflow during wakefulness. Such resetting is attributed to hypoxia-induced upregulation of peripheral chemoreceptor and brain stem sympathetic function. Whether recurrent arousal from sleep also influences daytime muscle...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2016-12, Vol.68 (6), p.1467-1474
Main Authors: Taylor, Keri S, Murai, Hisayoshi, Millar, Philip J, Haruki, Nobuhiko, Kimmerly, Derek S, Morris, Beverley L, Tomlinson, George, Bradley, T Douglas, Floras, John S
Format: Article
Language:eng
Subjects:
Age Factors
Arousal - physiology
Cohort Studies
Female
Humans
Male
Middle Aged
Oxygen Consumption - physiology
Polysomnography - methods
Predictive Value of Tests
Prognosis
Risk Assessment
Severity of Illness Index
Sex Factors
Sleep Apnea, Obstructive - physiopathology
Sympathetic Nervous System - physiopathology
Wakefulness - physiology
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Summary:Obstructive apnea during sleep elevates the set point for efferent sympathetic outflow during wakefulness. Such resetting is attributed to hypoxia-induced upregulation of peripheral chemoreceptor and brain stem sympathetic function. Whether recurrent arousal from sleep also influences daytime muscle sympathetic nerve activity is unknown. We therefore tested, in a cohort of 48 primarily nonsleepy, middle-aged, male (30) and female (18) volunteers (age59±1 years, mean±SE), the hypothesis that the frequency of arousals from sleep (arousal index) would relate to daytime muscle sympathetic burst incidence, independently of the frequency of apnea or its severity. Polysomnography identified 24 as having either no or mild obstructive sleep apnea (apnea–hypopnea index 15 events/h). Burst incidence correlated significantly with arousal index (r=0.53; P
ISSN:0194-911X
1524-4563