Reproducibility of quantitative indices of lung function and microstructure from 129 Xe chemical shift saturation recovery (CSSR) MR spectroscopy

To evaluate the reproducibility of indices of lung microstructure and function derived from Xe chemical shift saturation recovery (CSSR) spectroscopy in healthy volunteers and patients with chronic obstructive pulmonary disease (COPD), and to study the sensitivity of CSSR-derived parameters to pulse...

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Bibliographic Details
Published in:Magnetic resonance in medicine 2017-06, Vol.77 (6), p.2107
Main Authors: Stewart, Neil J, Horn, Felix C, Norquay, Graham, Collier, Guilhem J, Yates, Denise P, Lawson, Rod, Marshall, Helen, Wild, Jim M
Format: Article
Language:English
Subjects:
Administration, Inhalation
Adult
Aged
Female
Humans
Image Interpretation, Computer-Assisted - methods
Lung - pathology
Lung - physiopathology
Magnetic Resonance Imaging - methods
Magnetic Resonance Spectroscopy - methods
Male
Middle Aged
Pulmonary Disease, Chronic Obstructive - diagnostic imaging
Pulmonary Disease, Chronic Obstructive - pathology
Pulmonary Disease, Chronic Obstructive - physiopathology
Pulmonary Gas Exchange - physiology
Radiopharmaceuticals - administration & dosage
Radiopharmaceuticals - pharmacokinetics
Reproducibility of Results
Sensitivity and Specificity
Signal Processing, Computer-Assisted
Xenon Isotopes - administration & dosage
Xenon Isotopes - pharmacokinetics
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Summary:To evaluate the reproducibility of indices of lung microstructure and function derived from Xe chemical shift saturation recovery (CSSR) spectroscopy in healthy volunteers and patients with chronic obstructive pulmonary disease (COPD), and to study the sensitivity of CSSR-derived parameters to pulse sequence design and lung inflation level. Preliminary data were collected from five volunteers on three occasions, using two implementations of the CSSR sequence. Separately, three volunteers each underwent CSSR at three different lung inflation levels. After analysis of these preliminary data, five COPD patients were scanned on three separate days, and nine age-matched volunteers were scanned three times on one day, to assess reproducibility. CSSR-derived alveolar septal thickness (ST) and surface-area-to-volume (S/V) ratio values decreased with lung inflation level (P 
ISSN:1522-2594
DOI:10.1002/mrm.26310