Impact of platelet-rich plasma injection timing on healing of Achilles tendon injury in a rat model

The aim of this study was to evaluate the impact of the timing of platelet-rich plasma (PRP) application on the healing of Achilles tendon injury in a rat model. Fifty-four female Sprague-Dawley rats were divided into 4 groups: PRP preparation group (n=6); Achilles tendon tear and 150 µL of PRP rece...

Full description

Saved in:
Bibliographic Details
Published in:Acta orthopaedica et traumatologica turcica 2016, Vol.50 (3), p.366
Main Authors: Çirci, Esra, Akman, Yunus Emre, Şükür, Erhan, Bozkurt, Erol Rüştü, Tüzüner, Tolga, Öztürkmen, Yusuf
Format: Article
Language:English
Subjects:
Achilles Tendon - injuries
Animals
Biomechanical Phenomena
Disease Models, Animal
Female
Injections
Platelet-Rich Plasma
Rats
Rats, Sprague-Dawley
Time Factors
Wound Healing
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aim of this study was to evaluate the impact of the timing of platelet-rich plasma (PRP) application on the healing of Achilles tendon injury in a rat model. Fifty-four female Sprague-Dawley rats were divided into 4 groups: PRP preparation group (n=6); Achilles tendon tear and 150 µL of PRP received on the day following the injury (PRP day 0, group 1, n=16); Achilles tendon tear and 150 µL of PRP received on the third day following injury (day 3 , group 2, n=16); Achilles tendon tear and 150 µL of saline received on the day following injury (PRP day 0, group 3, n=16). Rats were sacrificed at 3 weeks. Consequently, biomechanical and histologic analyses were performed. According to histological evaluation, inflammation, fibroblast density, epitenon thickness, and collagen fiber were significantly higher in group 1 than in group 2 (p0.05). Based on histological criteria, results of the present study suggest that immediate injection of PRP for tendon injury improves tendon healing in rats. Although the use of PRP is well recognized in orthopedic surgery, we aimed to highlight the importance of immediate application of PRP for acute tendon injury.
ISSN:1017-995X
DOI:10.3944/AOTT.2015.15.0271