Biological activities of unique isoflavones prepared from Apios americana Medik

Four unique isoflavone aglycones (barpisoflavone A (1), 2′-hydroxygenistein (2), 5-methylgenistein (3), and gerontoisoflavone A (4)) whose structures were related to genistein were prepared from the tuber of Apios americana Medik. We examined the estrogen receptor and androgen receptor binding activ...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2016-04, Vol.80 (4), p.774-778
Main Authors: Kaneta, Haruna, Koda, Mina, Saito, Shun, Imoto, Masaya, Kawada, Manabu, Yamazaki, Yoko, Momose, Isao, Shindo, Kazuoshi
Format: Article
Language:English
Subjects:
antioxidant activity
Apios americana Medik
estrogen agonistic activity
Fabaceae - chemistry
isoflavone
Isoflavones - pharmacology
α-glucosidase inhibitory activity
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Summary:Four unique isoflavone aglycones (barpisoflavone A (1), 2′-hydroxygenistein (2), 5-methylgenistein (3), and gerontoisoflavone A (4)) whose structures were related to genistein were prepared from the tuber of Apios americana Medik. We examined the estrogen receptor and androgen receptor binding activities, estrogen agonistic activities, antioxidant activities, and α-glucosidase inhibitory activities of 1-4. The results obtained showed that 2 possessed potent and 1, 3, and 4 possessed moderate estrogen partial agonistic activities, 1 and 2 possessed moderate antioxidant activities, and 2 and 3 possessed moderate α-glucosidase inhibitory activities. Four unique isoflavone aglycones (barpisoflavone A (1), 2′-hydroxygenistein (2), 5-methylgenistein (3), and gerontoisoflavone A (4)) were prepared from the tuber of Apios americana Medik, and tested their biological activities.
ISSN:0916-8451
1347-6947
DOI:10.1080/09168451.2015.1127132