Characterization of α-, β- and p120-Catenin Expression in Feline Mammary Tissues and their Relation with E- and P-Cadherin

Abnormal catenin expression has been related to mammary carcinogenesis in both human and canine species and they are considered tumor- and invasion-suppressor molecules; however, in feline mammary tissues they have been scarcely studied. The immunohistochemical expression of α-, β- and p120-catenin...

Full description

Saved in:
Bibliographic Details
Published in:Anticancer research 2015-06, Vol.35 (6), p.3361
Main Authors: Figueira, Ana Catarina, Gomes, Catarina, Vilhena, Hugo, Miranda, Sónia, Carvalheira, Júlio, DE Matos, Augusto J F, Dias-Pereira, Patrícia, Gärtner, Fátima
Format: Article
Language:English
Subjects:
alpha Catenin - biosynthesis
Animals
beta Catenin - biosynthesis
Biomarkers, Tumor - biosynthesis
Breast Neoplasms - genetics
Breast Neoplasms - pathology
Breast Neoplasms - veterinary
Cadherins - biosynthesis
Carcinogenesis - genetics
Catenins - biosynthesis
Cats
Female
Gene Expression Regulation, Neoplastic
Humans
Immunohistochemistry
Mammary Glands, Animal - metabolism
Mammary Glands, Animal - pathology
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abnormal catenin expression has been related to mammary carcinogenesis in both human and canine species and they are considered tumor- and invasion-suppressor molecules; however, in feline mammary tissues they have been scarcely studied. The immunohistochemical expression of α-, β- and p120-catenin was studied in a series of normal feline mammary glands, hyperplastic/dysplastic lesions and benign and malignant mammary tumors. Their relationship with clinicopathological parameters and with E- and P-cadherin expression was assessed. Normal tissues, hyperplastic/dysplastic lesions and benign tumors expressed α-, β- and p120-catenin in the membrane of more than 75% of the luminal epithelial cells, while in malignant tumors, there was a reduction in their membranous expression and a p120-catenin cytoplasmic expression in 40%. Reduced α-catenin expression was related to tumor features with prognostic value, namely tumor size (p=0.0203) and necrosis (p=0.0205). The expression of α-, β- and p120-catenin were individually related to each other and collectively associated with E-cadherin expression. The results demonstrate a relationship between feline mammary carcinogenesis and decreased expression of catenins, suggesting that they may represent a valuable tool in the diagnosis of feline mammary neoplasms.
ISSN:1791-7530