A new triterpenoid from the fruits of Gardenia jasminoides var. radicans Makino

A novel triterpenoid 3α,16β,23,24-tetrahydroxy-28-nor-ursane-12,17,19,21-tetraen (1) was isolated from the fruits of Gardenia jasminoides var. radicans Makino. The structure of the new compounds was elucidated on the basis of spectroscopic analysis including MS and NMR data. Compound 1 was in vitro...

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Bibliographic Details
Published in:Natural product research 2015-04, Vol.29 (7), p.633-637
Main Authors: Qin, Fang-Min, Liu, Bai-Lian, Zhang, Ying, Zhou, Guang-Xiong
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Fruit - chemistry
Gardenia - chemistry
Gardenia jasminoides var. radicans
Hep G2 Cells
Humans
Inhibitory Concentration 50
iridoid glycoside
Molecular Structure
Plant Extracts - chemistry
Rubiaceae
Triterpenes - chemistry
Triterpenes - isolation & purification
ursane 28-nortriterpene
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Summary:A novel triterpenoid 3α,16β,23,24-tetrahydroxy-28-nor-ursane-12,17,19,21-tetraen (1) was isolated from the fruits of Gardenia jasminoides var. radicans Makino. The structure of the new compounds was elucidated on the basis of spectroscopic analysis including MS and NMR data. Compound 1 was in vitro tested for cytostatic activity on human throat cancer (Hep-2) cell line by 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide method and showed mild anticancer activity with the IC 50 of 31.2 μM.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2014.980249