Synthesis of the inosine 5′-monophosphate dehydrogenase (IMPDH) inhibitors

Inosine 5′-monophosphate dehydrogenase (IMPDH) is important molecular target for potential anticancer, antiviral, antibacterial and immunosuppressive agents. A lot of compounds were obtained to establish their activity toward this enzyme, and to improve therapeutic properties of IMPDH inhibitors use...

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Bibliographic Details
Published in:Journal of enzyme inhibition and medicinal chemistry 2015-08, Vol.30 (4), p.550-563
Main Authors: Cholewiński, Grzegorz, Iwaszkiewicz-Grześ, Dorota, Prejs, Michał, Głowacka, Agnieszka, Dzierzbicka, Krystyna
Format: Article
Language:English
Subjects:
Anticancer activity
antiviral activity
Enzyme Inhibitors - chemical synthesis
Enzyme Inhibitors - chemistry
Enzyme Inhibitors - pharmacology
IMP Dehydrogenase - antagonists & inhibitors
IMPDH inhibitors
mycophenolic acid
organic synthesis
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Summary:Inosine 5′-monophosphate dehydrogenase (IMPDH) is important molecular target for potential anticancer, antiviral, antibacterial and immunosuppressive agents. A lot of compounds were obtained to establish their activity toward this enzyme, and to improve therapeutic properties of IMPDH inhibitors used as the drugs. Some of the recently reported analogs exhibited promising results during in vitro and in vivo examinations in comparison to substances applied in clinic. In this review, we describe synthesis and biological activity evaluations of the newly designed IMPDH inhibitors.
ISSN:1475-6366
1475-6374
DOI:10.3109/14756366.2014.951349