Pancreatic Cancer Database: An integrative resource for pancreatic cancer

Pancreatic cancer is the fourth leading cause of cancer-related death in the world. The etiology of pancreatic cancer is heterogeneous with a wide range of alterations that have already been reported at the level of the genome, transcriptome, and proteome. The past decade has witnessed a large numbe...

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Bibliographic Details
Published in:Cancer biology & therapy 2014-08, Vol.15 (8), p.963-967
Main Authors: Thomas, Joji Kurian, Kim, Min-Sik, Balakrishnan, Lavanya, Nanjappa, Vishalakshi, Raju, Rajesh, Marimuthu, Arivusudar, Radhakrishnan, Aneesha, Muthusamy, Babylakshmi, Khan, Aafaque Ahmad, Sakamuri, Sruthi, Tankala, Shantal Gupta, Singal, Mukul, Nair, Bipin, Sirdeshmukh, Ravi, Chatterjee, Aditi, Prasad, T S Keshava, Maitra, Anirban, Gowda, Harsha, Hruban, Ralph H, Pandey, Akhilesh
Format: Article
Language:English
Subjects:
biomarker
body fluids
chronic pancreatitis
Databases, Genetic
Humans
Letter to the Editor
MicroRNAs - genetics
Pancreatic Neoplasms - genetics
Proteins - genetics
RNA, Messenger - genetics
secreted
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Summary:Pancreatic cancer is the fourth leading cause of cancer-related death in the world. The etiology of pancreatic cancer is heterogeneous with a wide range of alterations that have already been reported at the level of the genome, transcriptome, and proteome. The past decade has witnessed a large number of experimental studies using high-throughput technology platforms to identify genes whose expression at the transcript or protein levels is altered in pancreatic cancer. Based on expression studies, a number of molecules have also been proposed as potential biomarkers for diagnosis and prognosis of this deadly cancer. Currently, there are no repositories which provide an integrative view of multiple Omics data sets from published research on pancreatic cancer. Here, we describe the development of a web-based resource, Pancreatic Cancer Database ( http://www.pancreaticcancerdatabase.org ), as a unified platform for pancreatic cancer research. PCD contains manually curated information pertaining to quantitative alterations in miRNA, mRNA, and proteins obtained from small-scale as well as high-throughput studies of pancreatic cancer tissues and cell lines. We believe that PCD will serve as an integrative platform for scientific community involved in pancreatic cancer research.
ISSN:1538-4047
1555-8576
DOI:10.4161/cbt.29188