Amino Acid Substitutions in Polymerase Basic Protein 2 Gene Contribute to the Pathogenicity of the Novel A/H7N9 Influenza Virus in Mammalian Hosts

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Published in:Journal of Virology 2014-03, Vol.88 (6), p.3568-3576
Main Authors: Mok, Chris Ka Pun, Lee, Horace Hok Yeung, Lestra, Maxime, Nicholls, John Malcolm, Chan, Michael Chi Wai, Sia, Sin Fun, Zhu, Huachen, Poon, Leo Lit Man, Guan, Yi, Peiris, Joseph Sriyal Malik
Format: Article
Language:English
Subjects:
Amino Acid Substitution
Animals
Chickens
Cytokines - genetics
Cytokines - immunology
Female
Humans
Influenza A virus
Influenza A Virus, H7N9 Subtype - enzymology
Influenza A Virus, H7N9 Subtype - genetics
Influenza A Virus, H7N9 Subtype - isolation & purification
Influenza A Virus, H7N9 Subtype - pathogenicity
Influenza in Birds - genetics
Influenza in Birds - immunology
Influenza in Birds - virology
Influenza virus
Influenza, Human - genetics
Influenza, Human - immunology
Influenza, Human - virology
Mice
Mice, Inbred BALB C
Mutation, Missense
Pathogenesis and Immunity
Poultry Diseases - genetics
Poultry Diseases - immunology
Poultry Diseases - virology
RNA-Dependent RNA Polymerase - genetics
RNA-Dependent RNA Polymerase - metabolism
Viral Proteins - genetics
Viral Proteins - metabolism
Virulence
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Summary:Classifications Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0022-538X Online ISSN: 1098-5514 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JVI .asm.org, visit: JVI       
ISSN:0022-538X
1098-5514
DOI:10.1128/JVI.02740-13