Recovery of fine motor performance after ischemic damage to motor cortex is facilitated by cell therapy in the rhesus monkey

Abstract We investigated the efficacy on recovery of function following controlled cortical ischemia in the monkey of the investigational cell drug product, CNTO 0007. This drug contains a cellular component, human umbilical tissue-derived cells, in a proprietary thaw and inject formulation. Results...

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Bibliographic Details
Published in:Somatosensory & motor research 2013-12, Vol.30 (4), p.185-196
Main Authors: Moore, Tara L., Pessina, Monica A., Finklestein, Seth P., Kramer, Brian C., Killiany, Ronald J., Rosene, Douglas L.
Format: Article
Language:English
Subjects:
Animals
Brain Ischemia - complications
Brain Ischemia - pathology
Brain Ischemia - surgery
Cell- and Tissue-Based Therapy - methods
Disease Models, Animal
Electroencephalography
Functional Laterality - physiology
Hand Strength - physiology
Macaca mulatta
Male
Monkey
Motor Cortex - physiology
Motor Skills - physiology
Movement Disorders - etiology
Movement Disorders - surgery
Recovery of Function - physiology
Single-Blind Method
stroke
Upper Extremity - physiopathology
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Summary:Abstract We investigated the efficacy on recovery of function following controlled cortical ischemia in the monkey of the investigational cell drug product, CNTO 0007. This drug contains a cellular component, human umbilical tissue-derived cells, in a proprietary thaw and inject formulation. Results demonstrate significantly better recovery of motor function in the treatment group with no difference between groups in the volume or surface area of ischemic damage, suggesting that the cells stimulated plasticity.
ISSN:0899-0220
1369-1651
DOI:10.3109/08990220.2013.790806