The relationship between oxidative stress and nonalcoholic fatty liver disease: Its effects on the development of nonalcoholic steatohepatitis

Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are the most common underlying causes of chronic liver injury. They are associated with a wide spectrum of hepatic disorders including basic steatosis, steatohepatitis, and cirrhosis. The molecular and cellular mechanis...

Full description

Saved in:
Bibliographic Details
Published in:Redox report : communications in free radical research 2013-07, Vol.18 (4), p.127-133
Main Authors: Ucar, Fatma, Sezer, Sevilay, Erdogan, Serpil, Akyol, Sumeyya, Armutcu, Ferah, Akyol, Omer
Format: Article
Language:English
Subjects:
Animals
Antioxidants
Biomarkers - analysis
Disease Progression
Fatty Liver - complications
Fatty Liver - etiology
Humans
Inflammation
Iron - metabolism
Lipid Peroxidation
Liver
Liver Cirrhosis - etiology
Mitochondria, Liver - physiology
NAFLD
NASH
Non-alcoholic Fatty Liver Disease
Oxidative Stress
Reactive Oxygen Species - metabolism
Review
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are the most common underlying causes of chronic liver injury. They are associated with a wide spectrum of hepatic disorders including basic steatosis, steatohepatitis, and cirrhosis. The molecular and cellular mechanisms underlying hepatic injury in NAFLD and NASH are still unknown. This review describes the roles of oxidative stress and inflammatory responses in the pathogenesis of NAFLD and its progression to NASH.
ISSN:1351-0002
1743-2928
DOI:10.1179/1351000213Y.0000000050